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Influence of the growth cycle on the bioactive properties and phenolic composition of Cynara cardunculus L. var altilis

2019Conference object Open access
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dc.contributor.authorMandim, Filipa
dc.contributor.authorPetropoulos, Spyridon Α.
dc.contributor.authorDias, Maria Inês
dc.contributor.authorFernandes, Ângela
dc.contributor.authorPinela, José
dc.contributor.authorKostić, Marina
dc.contributor.authorSoković, Marina
dc.contributor.authorBarros, Lillian
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2021-10-25T13:16:09Z
dc.date.available2021-10-25T13:16:09Z
dc.date.issued2019
dc.description.abstractCynara cardunculus L. (syn. Cardoon), is an erect perennial herbaceous plant, native to the Mediterranean basin. It is characterized by a high variety and richness in compounds with health benefits. Also, its cultivation and economic impact are highly important due to the diverse industrial applications (i.e. vegetable rennet, biomass, bioenergy, etc.) [1, 2]. Due to its increasing consumption and commercial interest, this study purposes the analysis of phenolic compounds and bioactive properties of different cardoon parts (heads, bracts, and seeds) collected in Greece during different maturation stages.The phenolic composition was determined by HPLC-DAD-ESI/MS. The antibacterial and antifungal activities were evaluated by applying the microdilution method. The cytotoxic effects were evaluated in four human tumor cell lines using the sulforhodamine B assay, while the anti- inflammatory activity was evaluated through the inhibition of NO production in macrophage cells. Finally, the antioxidant activity was measured through the TBARS and OxHLIA assays. The content in phenolic compounds decreased with the maturation process, except in the seed extract. All the tested samples exhibited antibacterial and antifungal activity, where lower MICs were observed when the plant reached maturity. Regarding the cytotoxic and anti-inflammatory activities, the earliest harvest stages revealed the highest activity, except for seeds.Moreover, with the maturation process, extracts presented higher capacity to OxHLIA and TBARS inhibition. The heterogeneity of the biological results reveals that other compounds than phenolic ones may be correlated with these bioactivities. This study proved the high biological potential of cardoon parts as also its possible use as a source of important bioactive compounds. Nevertheless, further studies are needed to understand which compounds are responsible for the observed bioactivities, as well as to find the stage of maturity that provides the best bioactive properties.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.isbn978-84-8158-820-0
dc.identifier.urihttp://hdl.handle.net/10198/24077
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCardoonpt_PT
dc.subjectPolyphenolic profilept_PT
dc.subjectAntioxidant activitypt_PT
dc.subjectCytotoxic activitypt_PT
dc.subjectAntibacterial activitypt_PT
dc.titleInfluence of the growth cycle on the bioactive properties and phenolic composition of Cynara cardunculus L. var altilispt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceOurense, Espanhapt_PT
oaire.citation.titleIberian Congress of Phenolic Compoundspt_PT
person.familyNameMandim
person.familyNameDias
person.familyNameFernandes
person.familyNamePinela
person.familyNameBarros
person.familyNameFerreira
person.givenNameFilipa
person.givenNameMaria Inês
person.givenNameÂngela
person.givenNameJosé
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-idF318-9049-EB99
person.identifier.ciencia-id2A13-4BE6-C7CF
person.identifier.ciencia-id2015-0434-AE7C
person.identifier.ciencia-id771C-2B43-B108
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-6494-2326
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0002-0157-9873
person.identifier.orcid0000-0001-7523-1637
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridM-8242-2013
person.identifier.ridB-4466-2014
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id54392272800
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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