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The role of natural compounds in rat mammary cancer: the beneficial effects of Santolina chamaecyparissus L. aqueous extract

2024Journal article Open access
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dc.contributor.authorAzevedo, Tiago
dc.contributor.authorSilva, Jessica
dc.contributor.authorPeixoto, Francisco P.
dc.contributor.authorSilvestre-Ferreira, Ana C.
dc.contributor.authorGama, Adelina
dc.contributor.authorSeixas, Fernanda
dc.contributor.authorFinimundy, Tiane C.
dc.contributor.authorBarros, Lillian
dc.contributor.authorMatos, Manuela
dc.contributor.authorOliveira, Paula A.
dc.contributor.authorFaustino-Rocha, Ana
dc.contributor.authorValada, Abigaël
dc.contributor.authorAnjos, Lara
dc.contributor.authorMoura, Tânia
dc.contributor.authorFerreira, Rafaela
dc.contributor.authorSantos, Marlene
dc.contributor.authorPires, Maria João
dc.contributor.authorNeuparth, Maria João
dc.date.accessioned2024-01-24T13:53:22Z
dc.date.available2024-01-24T13:53:22Z
dc.date.issued2024
dc.description.abstractBreast cancer is the most diagnosed cancer among women, and a leading cause of death worldwide. Santolina chamaecyparissus L. is a plant with multiple health benefits, including anticancer and anti-diabetic properties. This study aimed to assess the chemopreventive effects of S. chamaecyparissus aqueous extract (SCE) in an animal model of mammary cancer. A total of 28 four-week-old female Wistar rats were divided into four groups: control, MNU-induced (IND), SCE-supplemented (SCE), and SCE+IND. SCE was added to drinking water (12.72 mg/kg body weight) ad libitum. MNU was administered via the intraperitoneal route at 50 days of age. Weekly monitoring of body weight, food/drink intake, humane endpoints, and number of mammary tumours were recorded. Twenty weeks after MNU administration, animals were sacrificed by anaesthetic overdose and a necropsy was performed. Blood samples were used to determine blood count and serum biochemistry analysis, while kidney and liver samples were analysed for oxidative stress. Tumour samples were collected for gene expression and histology studies. SCE chemical composition was analysed by LC-MS and contained 19 phenolic compounds, with the most abundant being myricetin-O-glucuronide and 1,3-O-dicaffeoylquinic acid. Two animals in the IND group were sacrificed due to exceeding the humane endpoint limits. SCE supplementation delayed mammary tumour development, reducing its volume and weight. SCE had a positive impact on haematological parameters, particularly the neutrophil-lymphocyte ratio (P=0.026). No significant differences were observed in serum biochemistry, except for creatinine kinase MB, or in oxidative stress markers. Gene expression analysis showed significantly reduced VEGF expression levels (P=0.0158) in tumours from SCE+IND. These findings suggest that SCE is deserving of further study to identify the individual compounds and to understand its influence on animal models during cancer development.pt_PT
dc.description.sponsorshipThis work was supported by National Funds by FCT ‒ Portuguese Foundation for Science and Technology, under the projects UIDB/04033/2020 (CITAB) and LA/P/0126/2020 (Inov4Agro), UIDB/00690/2020 and UIDP/00690/2020 (CIMO) and LA/P/0007/2021 (SusTEC).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAzevedo, Tiago; Silva, Jessica; Peixoto, Francisco P.; Silvestre-Ferreira, Ana C.; Gama, Adelina; Seixas, Fernanda; Finimundy, Tiane C.; Barros, Lillian; Matos, Manuela; Oliveira, Paula A.; Faustino-Rocha, Ana; Valada, Abigaël; Anjos, Lara; Moura, Tânia; Ferreira, Rafaela; Santos, Marlene; Pires, Maria João; Neuparth, Maria João (2024). The role of natural compounds in rat mammary cancer: the beneficial effects of Santolina chamaecyparissus L. aqueous extract. Veterinarska stanica. ISSN 0350-7149. 55:1, p. 45-61pt_PT
dc.identifier.doi10.46419/vs.55.1.3pt_PT
dc.identifier.eissn1849-1170
dc.identifier.issn0350-7149
dc.identifier.urihttp://hdl.handle.net/10198/29353
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherCroatian Veterinary Institutept_PT
dc.relationLA/P/0007/2021pt_PT
dc.relationCentre for the Research and Technology of Agro-Environmental and Biological Sciences
dc.relationInstitute for innovation, capacity building and sustainability of agri-food production
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBreast cancerpt_PT
dc.subjectWistar ratspt_PT
dc.subjectSantolina chamaecyparissuspt_PT
dc.subjectChemopreventionpt_PT
dc.subjectAnimal modelpt_PT
dc.titleThe role of natural compounds in rat mammary cancer: the beneficial effects of Santolina chamaecyparissus L. aqueous extractpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for the Research and Technology of Agro-Environmental and Biological Sciences
oaire.awardTitleInstitute for innovation, capacity building and sustainability of agri-food production
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04033%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0126%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.citation.endPage61pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage45pt_PT
oaire.citation.titleVeterinarska stanicapt_PT
oaire.citation.volume55pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameFinimundy
person.familyNameBarros
person.givenNameTiane C.
person.givenNameLillian
person.identifier469085
person.identifier.ciencia-id2F18-67B1-776A
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0003-3516-0795
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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