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Antioxidant Activity, Antiproliferative Activity, Antiviral Activity, NO Production Inhibition, and Chemical Composition of Essential Oils and Crude Extracts of Leaves, Flower Buds, and Stems of Tetradenia riparia

2024Journal article Open access
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dc.contributor.authorSena, Jéssica da Silva
dc.contributor.authorRodrigues, Selma Alves
dc.contributor.authorSakumoto, Karina
dc.contributor.authorInumaro, Rodrigo Sadao
dc.contributor.authorGonzález-Maldonado, Pamela
dc.contributor.authorMendez-Scolari, Emilio
dc.contributor.authorPiau, Ranulfo
dc.contributor.authorGonçalves, Daniela Dib
dc.contributor.authorMandim, Filipa
dc.contributor.authorVaz, Josiana A.
dc.contributor.authorGonçalves, José Eduardo
dc.contributor.authorSotelo, Pablo Hernan
dc.contributor.authorValle, Juliana Silveira do
dc.contributor.authorGazim, Zilda Cristiani
dc.date.accessioned2024-10-08T11:25:09Z
dc.date.available2024-10-08T11:25:09Z
dc.date.issued2024
dc.description.abstractThe chemical composition of extracts (CEs) and essential oils (EOs) from Tetradenia riparia leaves, flower buds, and stems was analyzed. Antiproliferative activity against tumor cell lines, NO production inhibition, and antioxidant and antiviral activities were assessed. The CEs contained flavonoids, phenolic acids, coumarins, and saturated fatty acids. The EOs included monoterpenes, oxygenated sesquiterpenes, and diterpenes. NO production inhibition ranged from 76 to 247 μg mL−1, and antiproliferative activity exhibited GI50 between 20 and >204 μg mL−1, with low cytotoxicity (SI: 1.08 to 4.75). Reactive oxygen species inhibition ranged from 45 to 82%. Antioxidant activity varied when determined by the 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay (IC50: 0.51 to 8.47 mg mL−1) and ferric reducing antioxidant power (0.35 to 0.81 μM ferrous sulfate per mg). The reduction in β-carotene–linoleic acid co-oxidation varied between 76.13 and 102.25%. The total phenolic content of CEs and EOs was 10.70 to 111.68 μg gallic acid mg−1. Antiviral activity against herpes simplex virus type 1 (HSV-1) showed an EC50 between 9.64 and 24.55 μg mL−1 and an SI between 8.67 and 15.04. Leaf EOs exhibited an EC50 of 9.64 μg mL−1 and an SI of 15.04. Our study unveils the diverse chemical composition and multifaceted pharmacological properties of T. riparia, demonstrating its potential as a valuable source of bioactive compounds for therapeutic applications.pt_PT
dc.description.sponsorshipThe authors thank Universidade Paranaense and UniCesumar, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brazil (CAPES) (finance code 001), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (finance code 310105/2021-8), and Fundação Araucária for the financial support and fellowships. This work was supported by national funds through FCT/MCTES (PIDDAC): CIMO, UIDB/00690/2020 (DOI: 10.54499/UIDB/00690/2020) and UIDP/00690/2020 (DOI: 10.54499/UIDP/00690/2020), and SusTEC, LA/P/0007/2020 (DOI: 10.54499/LA/P/0007/2020) and PINV20-006 CONACYT, Paraguay.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSena, Jéssica da Silva; Rodrigues, Selma Alves; Sakumoto, Karina; Inumaro, Rodrigo Sadao; González-Maldonado, Pamela; Mendez-Scolari, Emilio; Piau, Ranulfo; Gonçalves, Daniela Dib; Mandim, Filipa; Vaz, Josiana; Gonçalves, José Eduardo; Sotelo, Pablo Hernan; Valle, Juliana Silveira do; Gazim, Zilda Cristiani (2024). Antioxidant Activity, Antiproliferative Activity, Antiviral Activity, NO Production Inhibition, and Chemical Composition of Essential Oils and Crude Extracts of Leaves, Flower Buds, and Stems of Tetradenia riparia. Pharmaceuticals. ISSN 1424-8247. 17:7, p. 1-19pt_PT
dc.identifier.doi10.3390/ph17070888pt_PT
dc.identifier.issn1424-8247
dc.identifier.urihttp://hdl.handle.net/10198/30367
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBrazilian myrrhpt_PT
dc.subjectMonoterpene hydrocarbonspt_PT
dc.subjectOxygenated sesquiterpenespt_PT
dc.subject14-hidroxy-9-epi-caryophyllenept_PT
dc.subjectDiterpenolpt_PT
dc.subjectRosmariniquinonept_PT
dc.subjectAntiproliferativept_PT
dc.subjectCellular antioxidantpt_PT
dc.subjectHSV-1pt_PT
dc.titleAntioxidant Activity, Antiproliferative Activity, Antiviral Activity, NO Production Inhibition, and Chemical Composition of Essential Oils and Crude Extracts of Leaves, Flower Buds, and Stems of Tetradenia ripariapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0007%2F2020/PT
oaire.citation.issue7pt_PT
oaire.citation.startPage888pt_PT
oaire.citation.titlePharmaceuticalspt_PT
oaire.citation.volume17pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMandim
person.familyNameVaz
person.givenNameFilipa
person.givenNameJosiana A.
person.identifier.ciencia-idF318-9049-EB99
person.identifier.ciencia-id171B-88BA-64F5
person.identifier.orcid0000-0002-6494-2326
person.identifier.orcid0000-0002-6989-1169
person.identifier.scopus-author-id16305323200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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