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Phenolic compounds and bioactive properties of wild German and Roman chamomiles

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dc.contributor.authorGuimarães, Rafaela
dc.contributor.authorBarros, Lillian
dc.contributor.authorDueñas, Montserrat
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorCarvalho, Ana Maria
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorQueiroz, Maria João R.P.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2013-02-27T15:19:54Z
dc.date.available2013-02-27T15:19:54Z
dc.date.issued2012
dc.description.abstractNatural products represent a rich source of biologically active compounds and are an example of molecular diversity, with recognized potential in drug discovery. In the present work, methanolic extracts of Matricaria recutita L. (German chamomile) and Chamaemelum nobile L. (Roman chamomile) and their decoction and infusion (the most consumed preparations of these herbs) were submitted to an analysis of phenolic compounds and bioactivity evaluation. Phenolic compounds were characterized by HPLC-DAD/ESI-MS. The bioactivity of the samples was tested in human tumour cell lines (breast- MCF-7, non-small cell lung- NCI-H460, colon- HCT-15, cervical- HeLa and hepatocellular- HepG2 carcinomas), and the hepatotoxicity was evaluated using a porcine liver primary cell culture (non-tumour cells, PLP2) [1,2]. Methanolic extracts of both chamomiles presented the highest amount of phenolic compounds compared to decoction and infusion, although varying in their composition. Furthermore, it was observed a decrease in the amount of phenolic compounds in decoction preparations of both samples. The major compounds found were luteolin O-acylhexoside in German chamomile, and 5-O-caffeoylquinic acid and an apigenin derivative in Roman chamomile. Methanolic extract and infusion preparation of both herbs showed inhibitory activity of the growth of HCT-15 and HeLa cell lines, without hepatotoxicity (GI50>400 µg/mL). Roman chamomile methanolic extract presented the highest inhibitory activity for all the cell lines (GI50<168 µg/mL). Decoction of both herbs did not show inhibitory activity of the growth of none of the tested cell lines (GI50>400 µg/mL), which could indicate that this bioactivity might be related to the compounds (including phenolic compounds) that were not extracted or that were affected by the decoction procedure. Overall, both chamomiles, mainly the methanolic extracts, contain important phytochemicals with bioactive properties to be explored in the medicine, food, and cosmetic industries.por
dc.description.sponsorshipThe authors are grateful to strategic project PEst-OE/AGR/UI0690/2011 for financial support to CIMO. R. Guimarães, L. Barros and R. Calhelha thanks to FCT, POPH-QREN and FSE for their grants (SFRH/BD/78307/2011, SFRH/BPD/4609/2008 and SFRH/BPD/68344/2010). The GIP-USAL is financially supported by the Consolider-Ingenio 2010 Programme (FUN-C-FOOD, CSD2007-00063).por
dc.identifier.citationGuimarães, Rafaela; Barros, Lillian; Dueñas, Montserrat; Calhelha, Ricardo C.; Carvalho, Ana Maria; Santos-Buelga, Celestino; Queiroz, Maria João; Ferreira, Isabel C.F.R. (2012). Phenolic compounds and bioactive properties of wild German and Roman chamomiles. In 3º Encontro Nacional de Química Terapêutica e 1st Portuguese-Spanish-Brazilian Meeting on Medicinal Chemistry. Aveiropor
dc.identifier.urihttp://hdl.handle.net/10198/8190
dc.language.isoengpor
dc.peerreviewedyespor
dc.relationSFRH/BPD/4609/2008
dc.titlePhenolic compounds and bioactive properties of wild German and Roman chamomilespor
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F78307%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F68344%2F2010/PT
oaire.citation.conferencePlaceAveiropor
oaire.citation.title3º Encontro Nacional de Química Terapêutica e 1st Portuguese-Spanish-Brazilian Meeting on Medicinal Chemistry, 28 a 30 de Novembropor
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
person.familyNameBarros
person.familyNameCalhelha
person.familyNameCarvalho
person.familyNameFerreira
person.givenNameLillian
person.givenNameRicardo C.
person.givenNameAna Maria
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifierID G-7399-2011
person.identifier144781
person.identifier.ciencia-id9616-35CB-D001
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person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0001-5508-5935
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id20336503900
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
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