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Exploring the therapeutic potential of cannabinoids in cancer by modulating signaling pathways and addressing clinical challenges

2024Artigo científico Acesso aberto
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dc.contributor.authorFaiz, Manal Bint
dc.contributor.authorNaeem, Faiza
dc.contributor.authorIrfan, Muhammad
dc.contributor.authorAslam, Muhammad Adeel
dc.contributor.authorEstevinho, Leticia M.
dc.contributor.authorAteşşahin, Dilek Arslan
dc.contributor.authorAlshahrani, Asma M.
dc.contributor.authorCalina, Daniela
dc.contributor.authorKhan, Khushbukhat
dc.contributor.authorSharifi-Rad, Javad
dc.date.accessioned2024-10-21T13:43:24Z
dc.date.available2024-10-21T13:43:24Z
dc.date.issued2024
dc.description.abstractFor centuries, cannabinoids have been utilized for their medicinal properties, particularly in Asian and South-Asian countries. Cannabis plants, known for their psychoactive and non-psychoactive potential, were historically used for spiritual and remedial healing. However, as cannabis became predominantly a recreational drug, it faced prohibition. Recently, the therapeutic potential of cannabinoids has sparked renewed research interest, extending their use to various medical conditions, including cancer. This review aims to highlight current data on the involvement of cannabinoids in cancer signaling pathways, emphasizing their potential in cancer therapy and the need for further investigation into the underlying mechanisms. A comprehensive literature review was conducted using databases such as PubMed/MedLine, Google Scholar, Web of Science, Scopus, and Embase. The search focused on peer-reviewed articles, review articles, and clinical trials discussing the anticancer properties of cannabinoids. Inclusion criteria included studies in English on the mechanisms of action and clinical efficacy of cannabinoids in cancer. Cannabinoids, including Δ9-THC, CBD, and CBG, exhibit significant anticancer activities such as apoptosis induction, autophagy stimulation, cell cycle arrest, anti-proliferation, anti-angiogenesis, and metastasis inhibition. Clinical trials have demonstrated cannabinoids’ efficacy in tumor regression and health improvement in palliative care. However, challenges such as variability in cannabinoid composition, psychoactive effects, regulatory barriers, and lack of standardized dosing remain. Cannabinoids show promising potential as anticancer agents through various mechanisms. Further large-scale, randomized controlled trials are essential to validate these findings and establish standardized therapeutic protocols. Future research should focus on elucidating detailed mechanisms, optimizing dosing, and exploring cannabinoids as primary chemotherapeutic agents.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFaiz, Manal Bint; Naeem, Faiza; Irfan, Muhammad; Aslam, Muhammad Adeel; Estevinho, Leticia M.; Ateşşahin, Dilek Arslan; Alshahrani, Asma M.; Calina, Daniela; Khan, Khushbukhat; Sharifi-Rad, Javad (2024). Exploring the therapeutic potential of cannabinoids in cancer by modulating signaling pathways and addressing clinical challenges. Discover Oncology. ISSN 2730-6011. 15:490, p. 1-27pt_PT
dc.identifier.doi10.1007/s12672-024-01356-8pt_PT
dc.identifier.issn2730-6011
dc.identifier.urihttp://hdl.handle.net/10198/30466
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnticancer effectspt_PT
dc.subjectApoptosispt_PT
dc.subjectCannabinoidspt_PT
dc.subjectCBDpt_PT
dc.subjectΔ9-THCpt_PT
dc.subjectMetastasispt_PT
dc.subjectPharmacological mechanismspt_PT
dc.titleExploring the therapeutic potential of cannabinoids in cancer by modulating signaling pathways and addressing clinical challengespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage27pt_PT
oaire.citation.issue490pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleDiscover Oncologypt_PT
oaire.citation.volume15pt_PT
person.familyNameEstevinho
person.givenNameLetícia M.
person.identifier.ciencia-idBA14-09D6-A406
person.identifier.orcid0000-0002-9249-1948
person.identifier.scopus-author-id6506577664
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4a1d5ba2-1854-4ca5-89a4-73f35e964df9
relation.isAuthorOfPublication.latestForDiscovery4a1d5ba2-1854-4ca5-89a4-73f35e964df9

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