Advisor(s)
Abstract(s)
Ligustrum lucidum Aiton and its berries have been used in Chinese traditional medicine
for around two thousand years. In the present study, L. lucidium berries harvested in two regions
of Portugal were studied. Haemolytic activity and inhibition of oxidative haemolysis as well as the
enzyme inhibitory activities ( -amylase enzyme and acetylcholinesterase) were assessed. Results
suggest that the different biological activities varied according to the region where samples were
collected. Results demonstrated that the sample obtained from region R1 was the most efficient
extract for all parameters evaluated, presenting the lowest values of IC50, 10.67 0.46 g/mL for the
inhibition of erythrocyte oxidative haemolysis, 58.28 3.77 g/mL for the -amylase enzyme and
67.67 2.10 g/mL for the acetylcholinesterase inhibition. L. Lucidum berries may be an interesting
source of compounds for use in the development of the therapeutic armamentarium for diseases
where enzymatic disruption is believed to play a role.
Description
Keywords
Alzheimer’s disease Diabetes Enzyme inhibitory potential Ligustrum lucidum Aiton berries
Pedagogical Context
Citation
Paula, Vanessa B.; Delgado, Teresa; Campos, Maria Graça; Anjos, Ofélia; Estevinho, Leticia M. (2019). Enzyme inhibitory potential of ligustrum lucidum aiton berries. Molecules. ISSN 1420-3049. 24, p. 1-7