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Advisor(s)
Abstract(s)
The main goal of the present work is to clear demonstrate that the selection of the proper solvent composition is a key step for both analytical and preparative separations. A complete methodology developed in the last years inside the LSRE group will be described. Three real optimization case-studies will be presented: two non-steroidal anti-inflammatory drugs (the separation of ketoprofen and flurbiprofen enantiomers) and one antihypertensive drug (the separation of nadolol stereoisomers).
Description
Keywords
Chiral separation Simulated moving bed
Citation
Ribeiro, António E.; Rodrigues, A.E.; Pais, L.S. (2012). Methodologies for the separation of chiral drugs by liquid chromatography: from analytical to preparative scale. In XVIII Encontro Luso-Galego de Química. Vila Real, Portugal