Publication
Visualization and measurement of the cell-free layer (CFL) in a microchannel network
| dc.contributor.author | Bento, David | |
| dc.contributor.author | Fernandes, Carla S. | |
| dc.contributor.author | Pereira, Ana I. | |
| dc.contributor.author | Miranda, João Mário | |
| dc.contributor.author | Lima, Rui A. | |
| dc.date.accessioned | 2018-01-31T10:00:00Z | |
| dc.date.accessioned | 2018-02-01T09:37:43Z | |
| dc.date.available | 2018-01-31T10:00:00Z | |
| dc.date.available | 2018-02-01T09:37:43Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | In the past years, in vitro blood studies have revealed several significant hemodynamic phenomena that have played a key role in recent developments of biomedical microdevices for cells separation, sorting and analysis. However, the blood flow phenomena happening in complex geometries, such as microchannel networks, have not been fully understood. Thus, it is important to investigate in detail the blood flow behavior occurring at microchannel networks. In the present study, by using a high-speed video microscopy system, we have used two working fluids with different haematocrit (1% Hct and 15% Hct) and we have investigated the cell-free layer (CFL) in a microchannel network composed by asymmetric bifurcations. By using the Z Project method from the image analysis software ImageJ, it was possible to conclude that the successive bifurcations and confluences influence the formation of the CFL not only along the upper and lower wall of the microchannel but also at the region immediately downstream of the confluence apex. | en_EN |
| dc.description.sponsorship | The authors acknowledge the financial support provided by the project POCI-01-0145 FEDER-016861 (with associated reference PTDC/QEQ-FTT/4287/2014), UID/EMS/00532/2013 and UID/CEC/00319/2013 funded by FCT (Foundation for Science and Technology), through national funds (PIDDAC), and FEDER through COMPETE2020 - Programa Operacional Competitividade e Internacionalização (POCI). D. Bento acknowledges the PhD scholarship SFRH/BD/91192/2012 granted by FCT. The authors also acknowledge the financial support provided by the project Nos. UID/EMS/00532/2013 and UID/EMS/04077/2013 and the project Nos. UID/EMS/00532/2013, UID/EMS/04077/2013, POCI-01-0145-FEDER-007043, UID/CEC/00319/2013 | |
| dc.description.version | info:eu-repo/semantics/publishedVersion | en_EN |
| dc.identifier.citation | Bento, D.; Fernandes, C. S.; Pereira, A. I.; Miranda, J. M.; Lima, R. (2018). Visualization and measurement of the cell-free layer (CFL) in a microchannel network. Lecture Notes in Computational Vision and Biomechanics. ISSN 2212-9391. 27, p. 930-936 | en_EN |
| dc.identifier.doi | 10.1007/978-3-319-68195-5_101 | en_EN |
| dc.identifier.issn | 2212-9391 | |
| dc.identifier.uri | http://hdl.handle.net/10198/15380 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | en_EN |
| dc.title | Visualization and measurement of the cell-free layer (CFL) in a microchannel network | en_EN |
| dc.type | conference paper | |
| dspace.entity.type | Publication | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F91192%2F2012/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876/UID%2FEMS%2F00532%2F2013/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876/UID%2FCEC%2F00319%2F2013/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876/UID%2FEMS%2F04077%2F2013/PT | |
| oaire.fundingStream | SFRH | |
| oaire.fundingStream | 5876 | |
| oaire.fundingStream | 5876 | |
| oaire.fundingStream | 5876 | |
| person.familyName | Fernandes | |
| person.familyName | Pereira | |
| person.givenName | Carla S. | |
| person.givenName | Ana I. | |
| person.identifier.ciencia-id | F319-3D67-9DB7 | |
| person.identifier.ciencia-id | 0716-B7C2-93E4 | |
| person.identifier.orcid | 0000-0002-3138-7493 | |
| person.identifier.orcid | 0000-0003-3803-2043 | |
| person.identifier.rid | A-4269-2015 | |
| person.identifier.rid | F-3168-2010 | |
| person.identifier.scopus-author-id | 8253740700 | |
| person.identifier.scopus-author-id | 15071961600 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | en_EN |
| rcaap.type | conferenceObject | en_EN |
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