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Combined nandrolone and resistance training induced cardiac remodelling and oxidative stress despite enhanced cardiomyocyte contractility

2026Artigo científico Acesso aberto
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorMoraes, Alexa Alves de
dc.contributor.authorSuarez, Pedro Zavagli
dc.contributor.authorQuintão, Arthur Eduardo de Carvalho
dc.contributor.authorFontes, Beatriz Lana
dc.contributor.authorCosta, Sebastião Felipe Ferreira
dc.contributor.authorRocha, Carolina Camargos
dc.contributor.authorSoares, Leôncio Lopes
dc.contributor.authorLeite, Luciano Bernardes
dc.contributor.authorOliveira, Leandro Licursi
dc.contributor.authorReis, Emily Correna Carlo
dc.contributor.authorOliveira, Edilamar Menezes de
dc.contributor.authorForte, Pedro
dc.contributor.authorNatali, Antônio José
dc.contributor.authorCarneiro-Júnior, Miguel Araújo
dc.date.accessioned2026-02-25T10:02:47Z
dc.date.available2026-02-25T10:02:47Z
dc.date.issued2026
dc.description.abstractNandrolone decanoate (ND) is widely used by individuals engaged in resistance training (RT), yet their combined effects on cardiac function remain unclear. Objective To investigate the effects of RT and ND on cardiac structure and function, cellular contractility, Ca-2 (+) -handling protein expression, and redox balance in rats. Methods Thirty-two male Wistar rats were assigned to four groups: control (C), trained (C-T), ND (N), and trained ND (N-T). Animals received ND or saline for eight weeks, and RT was performed 3 x /week. Cardiac function was assessed by echocardiography, and isolated cardiomyocytes from the left and right ventricles (LV and RV) were evaluated for contractile function. Protein expression of Ca-2 (+) -handling regulators and oxidative stress markers was quantified. Results N-T increased LV and RV diameters by 25% and 33%, septal thickness by 41.7%, and reduced ejection fraction by 12.3% compared to N (p < 0.05). LV cardiomyocytes increased width by 29% and volume by 23% in N-T versus C-T (p <= 0.04). In LV, N-T showed greater contraction amplitude and velocity at 5 Hz (p = 0.04) and increased relaxation velocity at 1, 3, and 5 Hz (p < 0.01), with shorter time to peak contraction and 50% relaxation at 1 Hz versus N (p = 0.04). In RV, N-T increased contraction amplitude and velocity at 1 and 5 Hz, reduced time to peak at 1 and 3 Hz, shortened relaxation time at 1 Hz, and showed higher relaxation velocity than N and C-T (p < 0.02). Molecular analyses revealed reduced RyR2 expression (25% in LV and 9% in RV) and a 41% decrease in LV phospholamban in N-T versus C-T (p < 0.05). N-T also exhibited higher LV malondialdehyde compared to C-T (p = 0.03). Conclusion ND combined with RT induced adverse cardiac remodeling and impaired ventricular function, despite enhanced cardiomyocyte contractility, and intensified molecular and oxidative disturbances, indicating a maladaptive cardiac response. This is the first study to demonstrate regional differences in contractility and redox balance of isolated ventricular cardiomyocytes under ND plus RT.eng
dc.identifier.citationMoraes, Alexa Alves de; Suarez, Pedro Zavagli; Quintão, Arthur Eduardo de Carvalho; Fontes, Beatriz Lana; Costa, Sebastião Felipe Ferreira; Rocha, Carolina Camargos; Soares, Leôncio Lopes; Leite, Luciano Bernardes; Oliveira, Leandro Licursi; Reis, Emily Correna Carlo; Oliveira, Edilamar Menezes de; Forte, Pedro; Natali, Antônio José; Carneiro-Júnior, Miguel Araújo (2026). Combined nandrolone and resistance training induced cardiac remodelling and oxidative stress despite enhanced cardiomyocyte contractility. Plos One. ISSN 1932-6203. 21, p. 1-23
dc.identifier.doi10.1371/journal.pone.0340574
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10198/35850
dc.language.isoeng
dc.peerreviewedyes
dc.publisherPublic Library of Science
dc.relation.ispartofPLOS One
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectVentricular-function
dc.subjectTestosterone
dc.subjectExercise
dc.subjectDecanoate
dc.subjectRats
dc.subjectMuscle
dc.subjectHypertrophy
dc.subjectHeart
dc.subjectPhospholamban
dc.subjectEpidemiology
dc.titleCombined nandrolone and resistance training induced cardiac remodelling and oxidative stress despite enhanced cardiomyocyte contractilityeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage23
oaire.citation.startPage1
oaire.citation.titlePlos One
oaire.citation.volume21
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameForte
person.givenNamePedro
person.identifier.ciencia-id351B-B16B-79C7
person.identifier.orcid0000-0003-0184-6780
relation.isAuthorOfPublication3ecc6d1b-07a4-40d7-81f4-df6fd7b3d5b0
relation.isAuthorOfPublication.latestForDiscovery3ecc6d1b-07a4-40d7-81f4-df6fd7b3d5b0

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