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Arbutus unedo honey and propolis ameliorate acute kidney injury, acute liver injury, and proteinuria via hypoglycemic and antioxidant activity in streptozotocin-treated rats

2022Journal article Open access
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dc.contributor.authorTouzani, Soumaya
dc.contributor.authorAl-Wailib, Noori
dc.contributor.authorImtara, Hamada
dc.contributor.authorAboulghazia, Abderrazak
dc.contributor.authorHammasd, Nawal
dc.contributor.authorFalcão, Soraia
dc.contributor.authorVilas-Boas, Miguel
dc.contributor.authorEl Arabi, Ilham
dc.contributor.authorAl-Waili, Wail
dc.contributor.authorLyoussi, Badiâa
dc.date.accessioned2022-03-09T16:52:58Z
dc.date.available2022-03-09T16:52:58Z
dc.date.issued2022
dc.description.abstractBackground/Aims: Honey and propolis have biological and therapeutic effects in various pathological and clinical conditions such as hyperglycemia and diabetes. However, the combined use of honey and propolis has not been reported. The study evaluated the protective effect of Arbutus unedo honey, propolis and their combination in streptozotocin (STR)- induced hyperglycemia, acute kidney injury (AKI), liver injury, dyslipidemia, and proteinuria in male Wistar rats. Methods: The study identified physicochemical characteristics, mineral and antioxidant content, and antioxidant activity in honey and propolis. Rats were assigned to five groups, with five rats in each group; control, STR-treated, STR-treated + honey (1g/kg/ day), STR-treated + propolis (100 mg/day), and STR-treated + honey and propolis. On day 15, blood glucose, insulin, HBA1c, kidney function tests, liver enzymes, lipid profile, hemoglobin, and urine protein, creatinine, glucose, and electrolytes were analyzed. Liver, pancreas, and kidney tissues were studied histologically. The mineral component in honey and propolis was determined by atomic absorption spectrometry. Honey analysis was performed by HPLC. Chemical characterization of propolis was performed by LC/DAD/ESI-MSn . Measurement of blood and urine parameters was carried out with an automated analyzer (Architect c8000) and XT-1800i Automated Hematology Analyzer. Insulin concentration was determined by Elisa and insulin resistance was estimated by using HOMA-IR. Results: Honey and propolis contain a high quantity of antioxidants and exhibit in vitro antioxidant activity. In STR-treated rats, blood glucose, HBA1c, creatinine, blood urea, liver enzymes, and urine protein significantly increased compared to the control group (P<0.05), while insulin, hemoglobin, and body weight significantly decreased. Histological changes were evident in the pancreas, kidney, and liver tissues. These results indicated AKI, liver injury, and pancreatic injury, which was evident with reducing the number of the island of Langerhans and marked hyperglycemia. The use of honey and propolis significantly (P<0.05) attenuated liver and kidney injury, and proteinuria, and improved level of hemoglobin, HBA1c, and insulin toward the normal range. The combination of honey and propolis was more effective than honey or propolis individually (P<0.05). Conclusion: the combination of propolis and honey can prevent STR-induced AKI, liver injury, proteinuria, dyslipidemia, anemia, hyperglycemia, and body weight loss, most likely by their hypoglycemic and antioxidant activities.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTouzani, Soumaya; Al-Wailib, Noori; Imtarac, Hamada; Aboulghazia, Abderrazak; Hammasd, Nawal; Falcão, Soraia; Vilas-Boas, Miguel; El Arabi, Ilham; Al-Waili, Wail ; Lyoussia, Badiaa (2022). Arbutus unedo honey and propolis ameliorate acute kidney injury, acute liver injury, and proteinuria via hypoglycemic and antioxidant activity in streptozotocin-treated rats. Cellular Physiology and Biochemistry. ISSN 1015-8987. 56:1, p. 61-81pt_PT
dc.identifier.doi10.33594/000000496pt_PT
dc.identifier.eissn1421-9778
dc.identifier.issn1015-8987
dc.identifier.urihttp://hdl.handle.net/10198/25187
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectHoneypt_PT
dc.subjectPropolispt_PT
dc.subjectProteinuriapt_PT
dc.subjectAcute kidney injurypt_PT
dc.subjectLiver injurypt_PT
dc.subjectHyperglycemiapt_PT
dc.subjectStreptozotocinpt_PT
dc.titleArbutus unedo honey and propolis ameliorate acute kidney injury, acute liver injury, and proteinuria via hypoglycemic and antioxidant activity in streptozotocin-treated ratspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage81pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage66pt_PT
oaire.citation.titleCellular Physiology and Biochemistrypt_PT
oaire.citation.volume56pt_PT
person.familyNameFalcão
person.familyNameVilas-Boas
person.givenNameSoraia
person.givenNameMiguel
person.identifier711432
person.identifier1693134
person.identifier.ciencia-idD41A-6BED-4CBB
person.identifier.ciencia-idA918-C6FF-81A4
person.identifier.orcid0000-0003-3735-6951
person.identifier.orcid0000-0002-8665-5280
person.identifier.ridI-5949-2013
person.identifier.scopus-author-id14832459200
person.identifier.scopus-author-id6602648497
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication5746ab3e-8ffe-4e26-9a41-8392cf031f28
relation.isAuthorOfPublicationf58280c8-298b-4e4c-9f7c-4517300d3382
relation.isAuthorOfPublication.latestForDiscovery5746ab3e-8ffe-4e26-9a41-8392cf031f28

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