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Bioactive compounds and functional properties of herbal preparations of Cystus creticus L. collected from Rhodes Island

2022Journal article Open access
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dc.contributor.authorMocan, Andrei
dc.contributor.authorFernandes, Ângela
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorGavrilas, Laura
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorIvanov, Marija
dc.contributor.authorBarros, Lillian
dc.contributor.authorBabotă, Mihai
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2021-11-23T10:12:03Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2021-11-23T10:12:03Z
dc.date.issued2022
dc.description.abstractThe members of Cystus genus are perenial shrubs with a well-established use in traditional medicine. Among these, C. creticus is the most popular, herbal preparations obtained from its aerial parts being recognized as antimicrobial, antitumor and anti-inflammatory agents. The present study aimed to evaluate phytochemical profile and bioactive potential of aqueous and hydroethanolic extracts of C. creticus aerial parts harvested from two different areas of Rhodes island. LC-DAD-ESI/MSn analysis revealed the presence of myricetin and quercetin glycosides as main compounds, especially in aqueous extracts, being probably responsible for their enhanced antioxidant and antimicrobial potential. On the other side, hydroethanolic preparations exerted a strong anti-inflammatory and anti-biofilm activity. Our findings suggest that the use of solvents with intermediate polarity can assure the best recovery of bioactive compounds from C. creticus, increasing the extraction yield for other non-phenolic compounds which can enhance therapeutic potential of the extract through a synergistic action.en_EN
dc.description.sponsorshipThis work was supported by a grant of the Romanian Ministry of Education and Research, CNCS–UEFISCDI, project number PN-III-P2-2.1-PED-2019-5360. This research was funded by the Serbian Ministry of Education, Science and Technological Development (Contract No. 451–03–9/2021–14/200007). The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) and FEDER under Programme PT2020 for financial support to CIMO (UID/AGR/00690/2020); the national funding by FCT, P.I., through the institutional scientific employment program-contract for LB, RC, and ÂF contract.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationMocan, Andrei; Fernandes, Ângela; Calhelha, Ricardo C.; Gavrilas, Laura; Ferreira, Isabel C.F.R.; Sokovic, Marija Ivanov; Barros, Lillian; Babota, Mihai (2022). Bioactive compounds and functional properties of herbal preparations of Cystus creticus L. collected from Rhodes Island. Frontiers in Nutrition. ISSN 2296-861X. 9, p. 1-9en_EN
dc.identifier.doi10.3389/fnut.2022.881210en_EN
dc.identifier.issn2296-861X
dc.identifier.urihttp://hdl.handle.net/10198/24313
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.publisherMDPI
dc.relationMountain Research Center
dc.subjectBioactive compoundsen_EN
dc.subjectNatural antioxidanteen_EN
dc.subjectAntimicrobial compoundsen_EN
dc.subjectCystus creticusen_EN
dc.subjectHerbal preparationsen_EN
dc.titleBioactive compounds and functional properties of herbal preparations of Cystus creticus L. collected from Rhodes Islanden_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.citation.titleFrontiers in Nutrition
oaire.fundingStream6817 - DCRRNI ID
person.familyNameFernandes
person.familyNameCalhelha
person.familyNameFerreira
person.familyNameBarros
person.givenNameÂngela
person.givenNameRicardo C.
person.givenNameIsabel C.F.R.
person.givenNameLillian
person.identifier144781
person.identifier469085
person.identifier.ciencia-id2015-0434-AE7C
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9418-CF95-9919
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0002-0157-9873
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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