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Cytinus hypocistis (L.) L. and its great bioactive potential

2022Conference object Open access
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dc.contributor.authorSilva, Ana Rita
dc.contributor.authorGarcía, Pablo A.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorBarros, Lillian
dc.date.accessioned2022-07-11T16:04:50Z
dc.date.available2022-07-11T16:04:50Z
dc.date.issued2022
dc.description.abstractPlant-derived compounds have been extensively investigated to find novel active compounds as templates to mitigate the relative void of combinatorial chemistry, offering the potential to discover innovative structures that can lead to effective agents for various purposes [1]. Cytinus hypocistis (L.) L. is a wild edible parasitic plant on numerous members of the Cistaceae family. Although its biological properties were potentially attributed to its hydrolysable tannin content, its chemical composition was largely unknown, and the active substances not yet identified [2,3]. Thus, to decipher its potential applications, this work aimed at studying the bioactive properties and chemical composition of C. hypocistis. The plant material was collected in Castro Daire, Portugal. After lyophilisation, four different hydroethanolic extracts (whole plant, nectar chamber of the flower, petals, and stalks) were prepared and used for further analysis. The proximate composition was evaluated by AOAC official procedures; free sugars were determined using HPLC-RI, while organic acids were determined using UPLC-DAD [4]. Phenolic compounds were analysed by HPLC-DAD/ESI-MSn [4-6]. C. hypocistis extracts were tested for their antioxidant (OxHLIA and TBARS), antibacterial (MIC and MBC), anti-inflammatory (murine macrophage - RAW64.7), and wound healing (migration capacity of HaCaT cells) properties. Enzyme inhibitory properties for α-amylase, SARSCoV- 2 chymotrypsin-like protease, and tyrosinase were also evaluated. C. hypocistis study unveiled its nectar as a balanced source of nutrients. A correlation between its hydrolysable tannin content and bioactive properties was also established. Extracts exhibited broad-spectrum antibacterial activity and good antiinflammatory, antioxidant, and wound healing properties, together with the capacity to inhibit tyrosinase, α-amylase, and SARS-CoV-2 chymotrypsin-like protease. These results are significant evidence of the versatile profile of this plant. For bioactivity validation and mechanism investigation, further studies on fractionation, isolation, and compound characterisation are required.pt_PT
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020). A.R. Silva is grateful to FCT and FSE for her Doctoral Grant (SFRH/BD/145834/2019). L. Barros is grateful to F.C.T. and P.I. for their contracts through the institutional scientific employment programme. The authors are also thankful to ERDF throughpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, Ana Rita; García, Pablo A.; Ferreira, Isabel C.F.R.; Barros, Lillian (2022). Cytinus hypocistis (L.) L. and its great bioactive potential. In 1st Novel Food Webinar: Novel foods based on new ingredients, materials, and processes. Onlinept_PT
dc.identifier.urihttp://hdl.handle.net/10198/25636
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherInstituto Politécnico de Bragançapt_PT
dc.relationCytinus hypocistis L. L.: a case study for the development of an innovative, safe, and effective anti-photoaging cosmeceutical formulation
dc.relationMountain Research Center
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCytinus hypocistispt_PT
dc.titleCytinus hypocistis (L.) L. and its great bioactive potentialpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleCytinus hypocistis L. L.: a case study for the development of an innovative, safe, and effective anti-photoaging cosmeceutical formulation
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F145834%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.citation.conferencePlaceOnlinept_PT
oaire.citation.endPage23pt_PT
oaire.citation.startPage23pt_PT
oaire.citation.title1st Novel Food Webinar: Novel foods based on new ingredients, materials, and processespt_PT
oaire.fundingStreamPOR_NORTE
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSilva
person.familyNameFerreira
person.familyNameBarros
person.givenNameAna Rita
person.givenNameIsabel C.F.R.
person.givenNameLillian
person.identifierABD-5857-2020
person.identifier144781
person.identifier469085
person.identifier.ciencia-id0E1A-35C1-C79A
person.identifier.ciencia-id9418-CF95-9919
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0001-5819-9065
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridE-8500-2013
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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