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Tailoring swelling of alginate-gelatin hydrogel microspheres by crosslinking with calcium chloride combined with transglutaminase

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dc.contributor.authorPilipenko, Nadezhda
dc.contributor.authorGonçalves, Odinei Hess
dc.contributor.authorBona, Evandro
dc.contributor.authorFernandes, Isabel P.
dc.contributor.authorPinto, João A.
dc.contributor.authorSorita, Guilherme Dallarmi
dc.contributor.authorLeimann, Fernanda Vitória
dc.contributor.authorBarreiro, M.F.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2020-01-06T14:09:19Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2020-01-06T14:09:19Z
dc.date.issued2019
dc.description.abstractlginate-based hydrogels can find uses in a wide range of applications, including in the encapsulation field. This type of hydrogels is usually ionically crosslinked using calcium sources giving rise to products with limited internal crosslinking. In this work, it is hypothesized that the combination of alginate crosslinked by calcium chloride (external crosslinking; ionic mechanism) with gelatin crosslinked by transglutaminase (internal crosslinking; enzymatic induced mechanism) can be used to tailor the swelling behavior of alginate-based hydrogel microspheres. A systematic study was conducted by covering process variables such as gelatin content, TGase concentration, and CaCl2 contact time, added by statistic tools as central composite rotatable design (CCRD), principal component analysis (PCA) and multiobjective optimization, to map their effect on the resulting water content after production (expressed as swelling ratio), and swelling properties at pH 3 and 7. Among the studied variables, particle's swelling was mostly affected by the gelatin content and transglutaminase concentration.
dc.description.sponsorshipThis work was financially supported by Associate Laboratory LSRELCM (UID/EQU/50020/2019) funded by national funds through FCT/ MCTES (PIDDAC), and Foundation for Science and Technology (FCT, Portugal) and by CIMO (UID/AGR/00690/2019) trough FEDER under Program PT2020. The authors are grateful to CAPES, CNPq and Fundação Araucária for the support and also to Ajinomoto Foods Europe S.A.S. (France) for kindly provide the transglutaminase sample used in this work. I.P. Fernandes thanks the national funding by FCT, P.I., through the institutional scientific employment program-contract for her contract.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationPilipenko, Nadezhda; Gonçalves, Odinei Hess; Bona, Evandro; Fernandes, Isabel P.; Pinto, João A.; Sorita, Guilherme D.; Leimann, Fernanda Vitória; Barreiro, Maria Filomena (2019). Tailoring swelling of alginate-gelatin hydrogel microspheres by crosslinking with calcium chloride combined with transglutaminase. Carbohydrate Polymers. ISSN 0144-8617. 223, p. 1-9en_EN
dc.identifier.doi10.1016/j.carbpol.2019.115035en_EN
dc.identifier.issn0144-8617
dc.identifier.urihttp://hdl.handle.net/10198/20227
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationLaboratory of Separation and Reaction Engineering
dc.subjectAlginateen_EN
dc.subjectEnzymatic-induced crosslinkingen_EN
dc.subjectGelatinen_EN
dc.subjectHydrogel microspheresen_EN
dc.subjectIonic crosslinkingen_EN
dc.subjectSwellingen_EN
dc.titleTailoring swelling of alginate-gelatin hydrogel microspheres by crosslinking with calcium chloride combined with transglutaminaseen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleLaboratory of Separation and Reaction Engineering
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FEQU%2F50020%2F2019/PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameGonçalves
person.familyNameFernandes
person.familyNamePinto
person.familyNameLeimann
person.familyNameBarreiro
person.givenNameOdinei Hess
person.givenNameIsabel P.
person.givenNameJoão A.
person.givenNameFernanda Vitória
person.givenNameFilomena
person.identifier.ciencia-id4D1C-441F-C7F0
person.identifier.ciencia-idE518-E967-5179
person.identifier.ciencia-id8F10-A04D-FC0D
person.identifier.ciencia-id3418-47D5-5746
person.identifier.orcid0000-0002-9528-8187
person.identifier.orcid0000-0002-0069-4503
person.identifier.orcid0000-0002-6853-9921
person.identifier.orcid0000-0001-6230-9597
person.identifier.orcid0000-0002-6844-333X
person.identifier.ridL-1552-2016
person.identifier.ridL-9802-2014
person.identifier.scopus-author-id9335958400
person.identifier.scopus-author-id26323585300
person.identifier.scopus-author-id57208035714
person.identifier.scopus-author-id57188719717
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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