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Low cost microfluidic device for partial cell separation: micromilling approach

dc.contributor.authorLopes, Raquel
dc.contributor.authorRodrigues, Raquel Oliveira
dc.contributor.authorPinho, Diana
dc.contributor.authorValdemar, Garcia
dc.contributor.authorSchütte, Helmut
dc.contributor.authorLima, Rui A.
dc.contributor.authorGassmann, Stefan
dc.date.accessioned2015-07-31T10:18:22Z
dc.date.available2015-07-31T10:18:22Z
dc.date.issued2015
dc.description.abstractSeveral studies have already demonstrated that it is possible to perform blood flow studies in microfluidic systems fabricated by using low-cost techniques. However, most of these techniques do not produce microchannels smaller than 100 microns and as a result they have several limitations related to blood cell separation. Recently, manufacturers have been able to produce milling tools smaller than 100 microns, which consequently have promoted the ability of micromilling machines to fabricate microfluidic devices able to perform separation of red blood cells (RBCs) from plasma. In this work, we show the ability of a micromilling machine to manufacture microchannels with dimensions down to 30 microns. Additionally, we show for the first time the ability of the proposed microfluidic device to enhance the cell-free layer close to the walls, leading to perform partial separation of RBCs from plasma.por
dc.description.sponsorshipThe authors acknowledge the financial support provided by PTDC/SAU-ENB/116929/2010 and EXPL/EMSSIS/ 2215/2013 from FCT (Science and Technology Foundation), COMPETE, QREN and European Union (FEDER). RR and DP acknowledge, respectively, the PhD scholarships SFRH/BD/97658/2013 and SFRH/BD/89077/2012 attributed by FCT.
dc.identifier.citationLopes, Raquel; Rodrigues, Raquel O. ; Pinho, Diana; Garcia, Valdemar; Schutte, Helmut; Lima, Rui; Gassmann, Stefan (2015) . Low cost microfluidic device for partial cell separation: micromilling approach. In 2015 IEEE International Conference on Industrial Technology, ICIT 2015. Seville. p. 3347-3350. ISBN 978-1-4799-7800-7por
dc.identifier.doi10.1109/ICIT.2015.7125594
dc.identifier.isbn978-1-4799-7800-7
dc.identifier.urihttp://hdl.handle.net/10198/12014
dc.language.isoporpor
dc.peerreviewedyespor
dc.publisherIEEEpor
dc.relationBIOMIMETIC - A biomimetic microdevice for the diagnosis of erythrocytes diseases based on their deformability
dc.relationMAGNETIC CARBON NANOSTRUCTURES AND STUDY OF THEIR TRANSPORT IN MICROFLUIDIC DEVICES FOR HYPERTHERMIA
dc.subjectMicromillingpor
dc.subjectMicrofluidic devicepor
dc.subjectNonlithographic techniquepor
dc.subjectRed blood cellspor
dc.subjectCell-free layerpor
dc.titleLow cost microfluidic device for partial cell separation: micromilling approachpor
dc.typeconference paper
dspace.entity.typePublication
oaire.awardTitleBIOMIMETIC - A biomimetic microdevice for the diagnosis of erythrocytes diseases based on their deformability
oaire.awardTitleMAGNETIC CARBON NANOSTRUCTURES AND STUDY OF THEIR TRANSPORT IN MICROFLUIDIC DEVICES FOR HYPERTHERMIA
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-ENB%2F116929%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/EXPL%2FEMS-SIS%2F2215%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F97658%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F89077%2F2012/PT
oaire.citation.conferencePlaceSeville, Spainpor
oaire.citation.endPage3350por
oaire.citation.startPage3347por
oaire.citation.titleIndustrial Technologypor
oaire.fundingStream5876-PPCDTI
oaire.fundingStreamCOMPETE
oaire.fundingStreamSFRH
person.familyNamePinho
person.familyNameLima
person.givenNameDiana
person.givenNameRui A.
person.identifier.ciencia-id5214-ED0C-35E8
person.identifier.ciencia-idEE12-C3FB-349D
person.identifier.orcid0000-0002-3884-6496
person.identifier.orcid0000-0003-3428-637X
person.identifier.ridH-5157-2016
person.identifier.scopus-author-id18437397800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
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