Repository logo
 
Publication

Aloysia citrodora extract as a chemopreventive agent against HPV16-induced lesions: findings from K14-HPV16 mice

2024Journal article Open access
Simple item page
dc.contributor.authorMedeiros-Fonseca, Beatriz
dc.contributor.authorFaustino-Rocha, Ana
dc.contributor.authorSilva, Jessica
dc.contributor.authorSilva, Mónica
dc.contributor.authorPires, Maria João
dc.contributor.authorNeuparth, Maria João
dc.contributor.authorVala, Helena
dc.contributor.authorVasconcelos-Nóbrega, Cármen
dc.contributor.authorDias, Maria Inês
dc.contributor.authorBarros, Lillian
dc.contributor.authorGonçalves, Lio
dc.contributor.authorGaivão, Isabel
dc.contributor.authorBastos, Margarida M.S.M.
dc.contributor.authorFélix, Luís
dc.contributor.authorVenâncio, Carlos
dc.contributor.authorMedeiros, Rui
dc.contributor.authorCosta, Rui Miguel Gil
dc.contributor.authorOliveira, Paula A.
dc.date.accessioned2024-11-07T14:47:45Z
dc.date.available2024-11-07T14:47:45Z
dc.date.issued2024
dc.description.abstractAloysia citrodora has a long history of traditional use in treating various ailments. This study evaluated the in vivo chemopreventive efficacy and systemic toxicity of an extract of A. citrodora in a transgenic mouse model of HPV16 (human papillomavirus type 16)-induced cancer. Methods: The experiment involved six groups (n = 5): group 1 (G1, wild-type (WT), water), group 2 (G2, HPV, water), group 3 (G3, WT, 0.013 g/mL), group 4 (G4, HPV, 0.006 g/mL), group 5 (G5, HPV, 0.008 g/mL), and group 6 (G6, HPV, 0.013 g/mL). Throughout the assay, humane endpoints, body weight, food, and water consumption were recorded weekly. The internal organs and skin of the mice were collected for analysis after they were sacrificed. Toxicological parameters that were studied included hematological and biochemical blood markers, splenic and hepatic histology, and hepatic oxidative stress. Results: A. citrodora extract seems to reduce the incidence of dysplastic and in situ carcinoma skin lesions induced by HPV16 in this model, suggesting that dietary supplementation with concentrations of 0.008 g/mL and 0.013 g/mL may have beneficial chemopreventive effects. Conclusions: The extract did not induce any concentration-dependent toxicological effects on any of the parameters included in the study, indicating a favorable toxicological profile under these experimental conditions.pt_PT
dc.description.sponsorshipBeatriz Medeiros-Fonseca has a Ph.D. grant with number [2020.07675.BD] (https://doi.org/10.54499/ 2020.07675.BD); Jéssica Silva has a Ph.D. grant with number [2020.07999.BD] (https://doi.org/10.54499/ 2020.07999.BD); Mónica G. Silva has a Ph.D. grant with number [UI/BD/151320/2021] (https://doi.org/ 10.54499/UI/BD/151320/2021) financed by FCT (Foundation for Science and Technology) through FSE (European Social Fund). This work is supported by National Funds by FCT-Portuguese under projects: CITAB [UID/04033/2020] (https://doi.org/10.54499/UIDB/04033/2020); CERNAS [UIDB/00681/2020] (https://doi.org/10.54499/UIDB/00681/2020); LEPABE [UIDB/00511/2020] (https://doi.org/10.54499/ UIDB/00511/2020) and [UIDP/00511/2020] (https://doi.org/10.54499/UIDP/00511/2020); ALiCE [LA/P/0045/2020] (https://doi.org/10.54499/LA/P/0045/2020); CIMO [UIDB/00690/2020] (https:// doi.org/10.54499/UIDB/00690/2020) and [UIDP/00690/2020] (https://doi.org/10.54499/UIDP/00690/ 2020); SusTEC, [LA/P/0007/2020] (https://doi.org/10.54499/LA/P/0007/2020); by national funds through the FCT/MCTES (PIDDAC). Furthermore, national funding by FCT/P.I., through the institutional scientific employment program contract for Lilian Barros, Maria I. Dias (https://doi.org/10.54499/ CEECINST/00016/2018/CP1505/CT0004), Luís Félix (https://doi.org/10.54499/2021.00458.CEECIND/ CP1690/CT0001) contract. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMedeiros-Fonseca, Beatriz; Faustino-Rocha, Ana I.; Silva, Jéssica; Silva, Mónica G.; Pires, Maria João; Neuparth, Maria João; Vala, Helena; Vasconcelos-Nóbrega, Cármen; Dias, Maria I.; Barros, Lillian; Gonçalves, Lio; Gaivão, Isabel; Bastos, Margarida M. S. M.; Félix, Luís; Venâncio, Carlos; Medeiros, Rui; Costa, Rui Miguel Gil; Oliveira, Paula A. (2024). Aloysia citrodora extract as a chemopreventive agent against HPV16-induced lesions: findings from K14-HPV16 mice. Exploration of Medicine. ISSN 2692-3106. 5, p. 416-433pt_PT
dc.identifier.doi10.37349/emed.2024.00228pt_PT
dc.identifier.issn2692-3106
dc.identifier.urihttp://hdl.handle.net/10198/30515
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOpen Exploration Publishingpt_PT
dc.relationEstudo dos efeitos imunossupressores de Pteridium aquilinum e suas contribuições para o processo de carcinogénese induzido por papilomavírus.
dc.relationThe role of mitochondria in the toxicity induced by microplastics and their relationship with the type of diet
dc.relationCentre for the Research and Technology of Agro-Environmental and Biological Sciences
dc.relationResearch Center in Natural Resources, Environment and Society
dc.relationLaboratory for Process Engineering, Environment, Biotechnology and Energy
dc.relationLaboratory for Process Engineering, Environment, Biotechnology and Energy
dc.relationALICE - Associate Laboratory in Chemical Engineering
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.relationNot Available
dc.relationMenthol and Thymol loaded in mucoadhesive nanocapsules for the transportation of ornamental fish
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAloysia citrodorapt_PT
dc.subjectCancerpt_PT
dc.subjectHPV16pt_PT
dc.subjectNatural extractpt_PT
dc.subjectMouse modelpt_PT
dc.titleAloysia citrodora extract as a chemopreventive agent against HPV16-induced lesions: findings from K14-HPV16 micept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEstudo dos efeitos imunossupressores de Pteridium aquilinum e suas contribuições para o processo de carcinogénese induzido por papilomavírus.
oaire.awardTitleThe role of mitochondria in the toxicity induced by microplastics and their relationship with the type of diet
oaire.awardTitleCentre for the Research and Technology of Agro-Environmental and Biological Sciences
oaire.awardTitleResearch Center in Natural Resources, Environment and Society
oaire.awardTitleLaboratory for Process Engineering, Environment, Biotechnology and Energy
oaire.awardTitleLaboratory for Process Engineering, Environment, Biotechnology and Energy
oaire.awardTitleALICE - Associate Laboratory in Chemical Engineering
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardTitleNot Available
oaire.awardTitleMenthol and Thymol loaded in mucoadhesive nanocapsules for the transportation of ornamental fish
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/2020.07675.BD/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/2020.07999.BD/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//UI%2FBD%2F151320%2F2021/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04033%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00681%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00511%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00511%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0045%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0007%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00016%2F2018%2FCP1505%2FCT0004/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND4ed/2021.00458.CEECIND%2FCP1690%2FCT0001/PT
oaire.citation.endPage433pt_PT
oaire.citation.startPage416pt_PT
oaire.citation.titleExploration of Medicinept_PT
oaire.citation.volume5pt_PT
oaire.fundingStreamOE
oaire.fundingStreamOE
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC INST 2018
oaire.fundingStreamCEEC IND4ed
person.familyNameDias
person.familyNameBarros
person.givenNameMaria Inês
person.givenNameLillian
person.identifier469085
person.identifier.ciencia-id2A13-4BE6-C7CF
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridM-8242-2013
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication7ca8432b-e7f4-4116-a56e-9eba0d4403bd
relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublication.latestForDiscovery3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isProjectOfPublication95ddea9a-27f6-4fe4-b054-801e11caabeb
relation.isProjectOfPublicationd9afbd0a-81c7-4edc-b875-50b7835f67df
relation.isProjectOfPublication0f54bb8a-1e1c-4728-b7ff-ea7b2a25e868
relation.isProjectOfPublicationac4fb709-719a-450b-8c96-17592d46f5e9
relation.isProjectOfPublication7fae63a8-7595-42fe-b07a-77726299dd84
relation.isProjectOfPublication3dc964d1-7e48-491e-b143-bf17354161ae
relation.isProjectOfPublication38e4618f-e4d1-4899-9533-a92d33c6caa9
relation.isProjectOfPublicationc6751eb9-1747-4136-89dc-b13cb8c17810
relation.isProjectOfPublication29718e93-4989-42bb-bcbc-4daff3870b25
relation.isProjectOfPublication0aac8939-28c2-46f4-ab6b-439dba7f9942
relation.isProjectOfPublication6255046e-bc79-4b82-8884-8b52074b4384
relation.isProjectOfPublication66436649-ef5b-4546-8da2-df4cbbf85e84
relation.isProjectOfPublication7fcc01a3-7bf2-4eb3-8a1e-e029f1e8aafc
relation.isProjectOfPublication.latestForDiscovery7fae63a8-7595-42fe-b07a-77726299dd84

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Aloysia citrodora extract.pdf
Size:
9.19 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CIMO - Artigos em Revistas Indexados à WoS/Scopus