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Advisor(s)
Abstract(s)
Blood in large arteries may be treated as a homogenous fluid
from a macroscopic prospective. However, in reality blood is a
suspension of deformable cells in viscous fluid plasma. In microcirculation,
which comprises the smallest arteries and veins, the
flow behavior of individual blood cells and their interactions
provide the microrheological basis of flow properties of blood at
a macroscopic level. Hence, in microcirculation it is fundamental
to study the flow behavior of blood at cellular level. Several studies
on both individual and concentrated RBCs have already been
performed in the past. However, all studies used conventional
microscopes and also ghost cells to obtain visible trace
RBCs through the microchannel. The present study is concerned
in providing further insights into the microscale blood flow behavior
through microchannels by applying an emerging optical
technique known as confocal micro-PIV/PTV. The technique
consists of a spinning disk confocal microscope, high
speed camera and a diode-pumped solid state (DPSS) laser combined
with a single particle tracking (SPT) software (MtrackJ).
Detailed measurements on the motions of RBCs were measured
at different haematocrits (Hct) and the correspondent radial dispersion
coefficient was determined.
Description
Keywords
Microcirculation RBC dispersion Micro-PTV Red blood cells
Citation
Lima, R.; Ishikawa, T.; Imai, Y.; Fujiwara, H.; Takeda, M.; Matsuki, N.; Wada, S.; Yamaguchi, T. (2008). Dispersion of red blood cells in microchannels : a confocal micro-PTV assessment. In 20th Bioengineering Conference. Tokyo, Japan.