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Bio-guided fractionation of extracts of Geranium molle L.: relationship between phenolic profile and biological activity

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dc.contributor.authorGraça, Vânia C.
dc.contributor.authorDias, Maria Inês
dc.contributor.authorBarros, Lillian
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2019-01-07T16:24:17Z
dc.date.available2019-01-07T16:24:17Z
dc.date.issued2018
dc.description.abstractGeranium molle L. (Fig. l) has been used in the Portuguese folk medicine for the treatment of various ailments including cancer [l]. However, contrary to many Geranium species, the bioactivity and the phytochemical composition of G. molle are virtually unexplored. The first phase of this study consisted in the chemical characterization (nutritional value, free sugars, organic acids, fatty acids and tocopherols) of a G. molle sample from Trás-os-Montes, north-eastern Portugal. The bioactive properties of infusion and decoction (common forms of consumption) and of different organic extracts obtained by sequential extraction were also evaluated. G. molle was shown to be rich in carbohydrates and proteins, providing tocopherols and essential fatty acids. Amongst the various extracts, the acetone extract was found to have the highest content of phenolic compounds as well as the highest antioxidant and cytotoxic activities [2]. Following this preliminary evaluation, the most active extracts (acetone and methanol) were fractionated by column chromatography and the resulting fractions were evaluated for their antioxidant and cytotoxic activities. The bio-guided fractionation of the extracts resulted in several fractions with improved bioactivity in comparison with the corresponding crude extracts. The fractions obtained from the acetone extract consistently displayed the lowest EC50 and GI50 values and presented the highest content of total phenolic compounds. The phytochemical composition of the most bioactive fractions of the acetone and methanol extracts was included about thirty identified compounds, mainly flavonoids and phenolic acids, which could be identified for the first time in G. molle [3].pt_PT
dc.description.sponsorshipWork supported under the projects POCI-01-0145-FEDER-006958, UID/AGR/00690/2013 (CIMO) and UID/QUI/00616/ 2013 (CQ-VR). V.C. Graça thanks FCT for her grant (SFRH/BD/52542/2014) and L. Barras contract. The authors are also grateful to Interreg Espana-Portugal for financiai support through the project 0377_Iberphenol_6_E.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGraça, Vânia C.; Dias, Maria Inês; Barros, Lillian; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R. (2018). Bio-guided fractionation of extracts of Geranium molle L.: relationship between phenolic profile and biological activity. In XXIV Encontro Luso Galego de Química. Porto. ISBN 978-989-8124-24-1pt_PT
dc.identifier.isbn978-989-8124-24-1
dc.identifier.urihttp://hdl.handle.net/10198/18315
dc.language.isoporpt_PT
dc.peerreviewedyespt_PT
dc.relationSFRH/BD/52542/2014pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleBio-guided fractionation of extracts of Geranium molle L.: relationship between phenolic profile and biological activitypt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardNumberUID/AGR/00690/2013
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F00690%2F2013/PT
oaire.citation.conferencePlacePorto, Portugalpt_PT
oaire.citation.titleXXIV Encontro Luso Galego de Químicapt_PT
oaire.fundingStream5876
person.familyNameDias
person.familyNameBarros
person.familyNameCalhelha
person.familyNameFerreira
person.givenNameMaria Inês
person.givenNameLillian
person.givenNameRicardo C.
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id2A13-4BE6-C7CF
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridM-8242-2013
person.identifier.ridJ-3600-2013
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication7ca8432b-e7f4-4116-a56e-9eba0d4403bd
relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
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