Analytical methods for honeybee venom characterization

Mehdi, Iouraouine El; Falcão, Soraia; Boujraf, Saïd; Mustapha, Harandou; Campos, Maria G.; Vilas-Boas, Miguel

Publication

Analytical methods for honeybee venom characterization

2022Journal article

dc.contributor.author	Mehdi, Iouraouine El
dc.contributor.author	Falcão, Soraia
dc.contributor.author	Boujraf, Saïd
dc.contributor.author	Mustapha, Harandou
dc.contributor.author	Campos, Maria G.
dc.contributor.author	Vilas-Boas, Miguel
dc.date.accessioned	2023-02-08T14:04:15Z
dc.date.available	2023-02-08T14:04:15Z
dc.date.issued	2022
dc.description.abstract	The discovery of new drugs has benefited significantly from the development of research in venomics, increasing our understanding of the envenomation processes. It has been previously reported that honeybee venom (HBV) exhibits several pharmacological activities such as anti‑inflammatory, antibacterial, antimutagenic, radioprotective, and anticancer activity and may inclusively act as a complementary treatment for SARS‑CoV‑2. It composition consists mainly on melittin, phospholipase A2, and apamin but other constituents such as hyaluronidase, mast cell degranulating peptide and secapin are also relevant for its bioactivity. However, and because HBV is not officially recognized as a drug, until now, the international community did not establish quality standards for it. To uncover its exact composition, and boost the discovery of HBV‑derived drugs, a significant number of techniques were developed. In this review, a relevant overview of the so far published analytical methods for HBV characterization is organized with the aim to accelerate its future standardization. The literature search was performed within PubMed, Google Scholar, and Science Direct by selecting specific documents and exploring HBV evaluation.	pt_PT
dc.description.sponsorship	Thanks to the Foundation Science and Technology (FCT, Portugal) for support by national funds to CIMO (UIDB/00690/2020). The project PDR2020‑1.0.1‑FEADER‑031734: “DivInA‑Diversification and Innovation on Beekeeping Production” and to the European Regional Development Fund through the Regional Operational Program North 2020, within the scope of Project GreenHealth, Norte‑01‑0145‑FEDER‑000042. This research was also funded by (UI0204): UIDB/00313/2020, Center of Chemistry from Faculty of Sciences and Technology of University of Coimbra, Portugal.	pt_PT
dc.description.version	info:eu-repo/semantics/publishedVersion	pt_PT
dc.identifier.citation	Mehdi, Iouraouine El; Falcão, Soraia; Boujraf, Saïd; Mustapha, Harandou; Campos, Maria G.; Vilas-Boas, Miguel (2022). Analytical methods for honeybee venom characterization. Journal of Advanced Pharmaceutical Technology & Research. ISSN 2231-4040. 13:3, p. 154-160	pt_PT
dc.identifier.doi	10.4103/japtr.japtr_166_21	pt_PT
dc.identifier.issn	2231-4040
dc.identifier.issn	0976-2094
dc.identifier.uri	http://hdl.handle.net/10198/26816
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Wolters Kluwer	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	Analytical methods	pt_PT
dc.subject	Apamin	pt_PT
dc.subject	Enzymes	pt_PT
dc.subject	Mast cell degranulating peptide	pt_PT
dc.subject	Peptides	pt_PT
dc.subject	Venomics	pt_PT
dc.title	Analytical methods for honeybee venom characterization	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.citation.endPage	160	pt_PT
oaire.citation.issue	3	pt_PT
oaire.citation.startPage	154	pt_PT
oaire.citation.title	Journal of Advanced Pharmaceutical Technology & Research	pt_PT
oaire.citation.volume	13	pt_PT
person.familyName	Falcão
person.familyName	Vilas-Boas
person.givenName	Soraia
person.givenName	Miguel
person.identifier	711432
person.identifier	1693134
person.identifier.ciencia-id	D41A-6BED-4CBB
person.identifier.ciencia-id	A918-C6FF-81A4
person.identifier.orcid	0000-0003-3735-6951
person.identifier.orcid	0000-0002-8665-5280
person.identifier.rid	I-5949-2013
person.identifier.scopus-author-id	14832459200
person.identifier.scopus-author-id	6602648497
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT
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