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Evaluation of biological activity and optimization of lavender essential oil extraction (Lavandula angustifolia L.)

2022Conference object Open access
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dc.contributor.authorDias, Maria Inês
dc.contributor.authorSprea, Rafael M.
dc.contributor.authorHeleno, Sandrina A.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorBarros, Lillian
dc.contributor.authorCarocho, Márcio
dc.contributor.authorAmaral, Joana S.
dc.date.accessioned2023-03-17T10:56:44Z
dc.date.available2023-03-17T10:56:44Z
dc.date.issued2022
dc.description.abstractMedicinal and aromatic plants (MAPs) are an important source of natural products, which have gained importance as alternatives in the prevention and treatment of diseases, besides being used as raw material for various industries [1]. Lavandula angustifolia L. is one of the most famous aromatic and medicinal plants [2]. Due to its composition, the essential oil of L. angustifolia is reported to have analgesic, sedative, antiseptic, diuretic, cytotoxic, anti-inflammatory, and antioxidant properties [3]. In this sense, the lavender essential oil was obtained by two different methodologies, conventional hydrodistillation by clevenger apparatus according to the European Pharmacopoeia, and non-conventional, microwave-assisted hydrodistillation, in which an experimental design was carried out to optimize the process. The optimal point was obtained by a Response Surface Methodology (RSM), using three variables, namely, Time (minutes),Temperature (ºC), and Power (W) to obtain high contents of linalool and linalool acetate, for which biological activities, such as antimicrobial, have been described. The oils obtained were analyzed by gas chromatography coupled to mass spectrometry, verifying the predominance of oxygenated monoterpenes (79.5-86.4%), with linalool (30.2-29.99%) and linalool acetate (25.6-37.7%) as the main compounds. Antioxidant activity was evaluated through three in vitro methodologies, namely reducing power (RP), 2,2-diphenyl-1 picrylhydrazyl (DPPH) radical-scavenging activity and cellular antioxidant activity (CAA). Furthermore, cytotoxicity activity was evaluated by the sulforhodamine B method, and antimicrobial activity was tested by the microdilution method.The results obtained show that lavender essential oil exhibits an excellent antioxidant, anti-inflammatory and antimicrobial activity, with particularly interesting results for fungistatic activity. Among the obtained essential oils, the microwave extracts rich in linalool and the extract obtained by clevenger hydrodistillation showed the best results for DPPH and PR assays, while no significant differences were obtained for the cellular antioxidant activity assay and anti-inflammatory activity. The extract obtained by clevenger showed better performance in antimicrobial activity. The oils showed cytotoxic activity for liver cells at the maximum concentration tested, and no toxicity was observed for the concentrations presenting anti-inflammatory activity.pt_PT
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES (PIDDAC) to CIMO (UIDB/00690/2020 and UIDP/00690/2020) and SusTEC (LA/P/0007/2021); national funding by FCT, P.I., through the institutional and individual scientific employment program-contract for L. Barros, R.C. Calhelha and Rafael Mascoloti Spréa (2020.08092.BD). S.A. Heleno thanks FCT for her individual employment program–contract (CEECIND/03040/2017).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDias, Maria Inês; Sprea, Rafael M.; Heleno, Sandrina A.; Calhelha, Ricardo C.; Barros, Lillian; Carocho, Márcio; Amaral, Joana S. (2022). Evaluation of biological activity and optimization of lavender essential oil extraction (Lavandula angustifolia L.). In 1st International Congress on Food, Nutrition & Public Health – Towards a Sustainable Future (ICFNH 2022): Book of Abstracts. Lisboapt_PT
dc.identifier.urihttp://hdl.handle.net/10198/27805
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherInstituto Nacional de Saúde Doutor Ricardo Jorgept_PT
dc.relationLA/P/0007/2021pt_PT
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationNutHealth: Exploitation of by-product from nut-press-cake as a source of natural health-enhancing ingredients
dc.relationNot Available
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectLavandula angustifolia L.)pt_PT
dc.subjectResearch Subject Categories::TECHNOLOGY::Chemical engineering::Food technologypt_PT
dc.titleEvaluation of biological activity and optimization of lavender essential oil extraction (Lavandula angustifolia L.)pt_PT
dc.typeconference object
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oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleNutHealth: Exploitation of by-product from nut-press-cake as a source of natural health-enhancing ingredients
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/2020.08092.BD/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F03040%2F2017%2FCP1403%2FCT0001/PT
oaire.citation.conferencePlaceLisboapt_PT
oaire.citation.endPage52pt_PT
oaire.citation.startPage52pt_PT
oaire.citation.title1st International Congress on Food, Nutrition & Public Health – Towards a Sustainable Future (ICFNH 2022): Book of Abstractspt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_NORTE
oaire.fundingStreamCEEC IND 2017
person.familyNameDias
person.familyNameSprea
person.familyNameHeleno
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person.familyNameBarros
person.familyNameCarocho
person.familyNameAmaral
person.givenNameMaria Inês
person.givenNameRafael M.
person.givenNameSandrina A.
person.givenNameRicardo C.
person.givenNameLillian
person.givenNameMárcio
person.givenNameJoana S.
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person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-8978-4547
person.identifier.orcid0000-0002-3648-7303
person.identifier.ridM-8242-2013
person.identifier.ridL-5951-2014
person.identifier.ridJ-2172-2014
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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