Publication
Synthesis of novel 2-Butadienylchromone derivatives
| dc.contributor.author | Albuquerque, Hélio | |
| dc.contributor.author | Santos, Clementina M.M. | |
| dc.contributor.author | Esteves, Cátia | |
| dc.contributor.author | Silva, Artur | |
| dc.contributor.author | Cavaleiro, José | |
| dc.date.accessioned | 2013-03-12T15:48:32Z | |
| dc.date.available | 2013-03-12T15:48:32Z | |
| dc.date.issued | 2012 | |
| dc.description.abstract | Chromones are a group of naturally occurring compounds with a benzoannelated ypyrone ring. A large number of chromone derivatives have been isolated from natural sources and a wide range of biological properties have been attribute to them, such as antifungal, anti-allergenic, antiviral, antitubulin, anti-hypertensive, anticancer and antioxidant activities.1 11 Studies with 2-styrylchromones demonstrated that the number and position of the hydroxyl groups in the A-ring and the 3', 4'-dihydroxy substitution on B-ring play an important role in their radical scavenger activity. In addition the molecular stabilization promoted by the carbonyl carbon C-4 and Ca=C~ double bond, also seem to contribute to the scavenging effect of these compounds. 121 Taking into account these considerations we establi sh a new synthetic route for the preparation of novel hydroxylated 2-butadienylchromone derivatives 5. Our methodology involves the condensation of methoxy-2-methylchromones zl31 with 3,4-dimethoxy- cinnamaldehyde 3141 leading to (E,E)-2-( 4-arylbuta-1 ,3-dien-l-yl)-4H-chromen-4-ones 4. The final step involves the cleavage of methyl group of 4 in order to obtain the desired hydroxylated derivatives 5 (Scheme). In this communication we will present the synthetic details of all described transformations as well as the structural characterisation (by ID and 2D NMR studies) of the new synthesi sed compounds. | por |
| dc.identifier.citation | Albuquerque, Hélio; Santos, Clementina M. M.; Esteves, Cátia; Silva, Artur; Cavaleiro, José (2012). Synthesis of novel 2-Butadienylchromone derivatives. In 3º Encontro Nacional de Química Terapêutica. Aveiro | por |
| dc.identifier.uri | http://hdl.handle.net/10198/8248 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.title | Synthesis of novel 2-Butadienylchromone derivatives | por |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Aveiro, Portugal | por |
| oaire.citation.title | 3º Encontro Nacional de Química Terapêutica | por |
| person.familyName | Santos | |
| person.givenName | Clementina M.M. | |
| person.identifier.ciencia-id | 9018-DB9C-C590 | |
| person.identifier.orcid | 0000-0003-4380-7990 | |
| person.identifier.scopus-author-id | 7201458663 | |
| rcaap.rights | openAccess | por |
| rcaap.type | conferenceObject | por |
| relation.isAuthorOfPublication | 64f662b6-775d-4ea0-bfd7-f527af0ac1a0 | |
| relation.isAuthorOfPublication.latestForDiscovery | 64f662b6-775d-4ea0-bfd7-f527af0ac1a0 |