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Separation of nadolol racemates by high pH reversed-phase preparative fixed-bed chromatography: comparison of C18 materials

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dc.contributor.authorArafah, Rami
dc.contributor.authorRibeiro, António E.
dc.contributor.authorRodrigues, Alírio
dc.contributor.authorPais, Luís S.
dc.date.accessioned2020-06-15T16:20:02Z
dc.date.available2020-06-15T16:20:02Z
dc.date.issued2018
dc.description.abstractFixed-Bed technology will be used for the multicomponent preparative separation of a pharmaceutical beta-blocker chiral drug. New strategies using different achiral stationary phases will be presented. Nadolol is a quaternary mixture of equal amounts of four stereoisomers and will be used as case-study. A new methodology for the design, optimization and experimental implementation of the multicomponent separation will be introduced, including the use of three different achiral adsorbents, the screening and choice of the best adsorbent-solvent combination, taking in account the final preparative separation using the fixed-bed technology. Extensive experimental and simulation results will be presented, including solvent screening, measurement of equilibrium adsorption isotherms, breakthrough measurements, and fixed-bed (Azura prep HPLC unit) experimental preparative separation using C18 columns under reversed-phase mode.pt_PT
dc.description.sponsorship“AIProcMat@N2020 - Advanced Industrial Processes and Materials for a Sustainable Northern Region of Portugal 2020”, with the reference NORTE-01-0145-FEDER-000006, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), and of project POCI-01-0145-FEDER-006984 – Associate Laboratory LSRE-LCM funded by ERDF through COMPETE2020 - Programa Operacional Competitividade e Internacionalização (POCI) – and by national funds through FCT - Fundação para a Ciência e Tecnologia.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.isbn978-972-789-566-3
dc.identifier.urihttp://hdl.handle.net/10198/22058
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherUniversidade de Aveiropt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectNadolol racematespt_PT
dc.subjectChiral and achiralpt_PT
dc.subjectFixed-Bedpt_PT
dc.titleSeparation of nadolol racemates by high pH reversed-phase preparative fixed-bed chromatography: comparison of C18 materialspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceAveiro, Portugalpt_PT
oaire.citation.title13th INTERNATIONAL CHEMICAL AND BIOLOGICAL ENGINEERING CONFERENCEpt_PT
person.familyNameArafah
person.familyNameRibeiro
person.familyNamePais
person.givenNameRami
person.givenNameAntónio E.
person.givenNameLuís S.
person.identifier.ciencia-idAB16-ECBF-B886
person.identifier.ciencia-id3211-D5B0-870D
person.identifier.ciencia-id421E-0CCD-A84F
person.identifier.orcid0000-0002-7743-4988
person.identifier.orcid0000-0003-4569-7887
person.identifier.orcid0000-0002-3000-2862
person.identifier.scopus-author-id57151342900
person.identifier.scopus-author-id23390701300
person.identifier.scopus-author-id6603930478
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication3cd4864a-8aa6-46a2-9415-767a7551ee62
relation.isAuthorOfPublication52666376-f100-4407-87ef-dc5df3613761
relation.isAuthorOfPublicationc6d25534-8487-45b1-90af-d350f4e3ac55
relation.isAuthorOfPublication.latestForDiscoveryc6d25534-8487-45b1-90af-d350f4e3ac55

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