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Orientador(es)
Resumo(s)
Fixed-Bed technology will be used for the multicomponent
preparative separation of a pharmaceutical beta-blocker chiral drug.
New strategies using different achiral stationary phases will be
presented. Nadolol is a quaternary mixture of equal amounts of four
stereoisomers and will be used as case-study. A new methodology
for the design, optimization and experimental implementation of the
multicomponent separation will be introduced, including the use of
three different achiral adsorbents, the screening and choice of the
best adsorbent-solvent combination, taking in account the final
preparative separation using the fixed-bed technology. Extensive
experimental and simulation results will be presented, including
solvent screening, measurement of equilibrium adsorption isotherms,
breakthrough measurements, and fixed-bed (Azura prep HPLC unit)
experimental preparative separation using C18 columns under
reversed-phase mode.
Descrição
Palavras-chave
Nadolol racemates Chiral and achiral Fixed-Bed
Contexto Educativo
Citação
Editora
Universidade de Aveiro