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Magnetoliposomes containing calcium ferrite nanoparticles for applications in breast cancer therapy

2019Journal article Open access
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dc.contributor.authorPereira, Daniela S.M.
dc.contributor.authorCardoso, Beatriz D.
dc.contributor.authorRodrigues, Ana Rita O.
dc.contributor.authorAmorim, Carlos O.
dc.contributor.authorAmaral, Vítor S.
dc.contributor.authorAlmeida, Bernardo G.
dc.contributor.authorQueiroz, Maria João R.P.
dc.contributor.authorMartinho, Olga
dc.contributor.authorBaltazar, Fátima
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorCoutinho, Paulo J.G.
dc.contributor.authorCastanheira, Elisabete M.S.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2020-01-06T14:10:17Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2020-01-06T14:10:17Z
dc.date.issued2019
dc.description.abstractMagnetoliposomes containing calcium ferrite (CaFe2O4) nanoparticles were developed and characterized for the first time. CaFe2O4 nanoparticles were covered by a lipid bilayer or entrapped in liposomes forming, respectively, solid or aqueous magnetoliposomes as nanocarriers for new antitumor drugs. The magnetic nanoparticles were characterized by UV/Visible absorption, XRD, HR-TEM, and SQUID, exhibiting sizes of 5.2 +/- 1.2 nm (from TEM) and a superparamagnetic behavior. The magnetoliposomes were characterized by DLS and TEM. The incorporation of two new potential antitumor drugs (thienopyridine derivatives) specifically active against breast cancer in these nanosystems was investigated by fluorescence emission and anisotropy. Aqueous magnetoliposomes, with hydrodynamic diameters around 130 nm, and solid magnetoliposomes with sizes of ca. 170 nm, interact with biomembranes by fusion and are able to transport the antitumor drugs with generally high encapsulation effciencies (>=70%). These fully biocompatible drug-loaded magnetoliposomes can be promising as therapeutic agents in future applications of combined breast cancer therapy.
dc.description.sponsorshipThis research was funded by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding of CF-UM-UP (UID/FIS/04650/2013; UID/FIS/04650/2019), CQUM (UID/QUI/00686/2016; UID/QUI/00686/2019) and LA-26 (PEst-C/SAU/LA0026/2013), and through the research project PTDC/QUI-QFI/28020/2017 (POCI-01-0145-FEDER-028020), financed by FCT, European Fund of Regional Development (FEDER), COMPETE2020 and Portugal2020. The magnetic measurements were supported by projects UTAP-EXPL/NTec/0046/2017, NORTE-01-0145-FEDER-028538 e PTDC/FIS-MAC/29454/2017. The APC was also funded by FCT. B.D.C. acknowledges FCT for a PhD grant (SFRH/BD/141936/2018).
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationPereira, Daniela S.M.; Cardoso, Beatriz D.; Rodrigues, Ana Rita O.; Amorim, Carlos O.; Amaral, Vítor S.; Almeida, Bernardo G.; Queiroz, Maria João R.P.; Martinho, Olga; Baltazar, Fátima; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Coutinho, Paulo J.G.; Castanheira, Elisabete M.S. (2019). Magnetoliposomes containing calcium ferrite nanoparticles for applications in breast cancer therapy. Pharmaceutics. ISSN 1999-4923. 11, p. 1-1-21en_EN
dc.identifier.doi10.3390/pharmaceutics11090477en_EN
dc.identifier.issn1999-4923
dc.identifier.urihttp://hdl.handle.net/10198/20266
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.subjectBreast cancer therapyen_EN
dc.subjectCalcium ferrite nanoparticlesen_EN
dc.subjectMagnetoliposomesen_EN
dc.subjectNew antitumor drugsen_EN
dc.subjectThienopyridine derivativesen_EN
dc.titleMagnetoliposomes containing calcium ferrite nanoparticles for applications in breast cancer therapyen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FFIS%2F04650%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PEst-C%2FSAU%2FLA0026%2F2013/PT
oaire.fundingStream5876
oaire.fundingStreamCOMPETE
person.familyNameCalhelha
person.familyNameFerreira
person.givenNameRicardo C.
person.givenNameIsabel C.F.R.
person.identifier144781
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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