The cation effect on the aqueous solubility of amino acids in the presence of salts : experimental and molecular dynamics simulation studies

Tomé, L.I.N.; Pinho, Simão; Jorge, M.; Gomes, J.R.B.; Coutinho, João A.P.

http://hdl.handle.net/10198/10524

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Abstract(s)

The study of the solubility behavior of amino acids and proteins in aqueous electrolyte solutions is of utmost importance to understand the biochemistry of natural systems, develop medical and pharmaceutical responses to diseases induced by biochemical disorders and improve the efficiency of biotechnological processes. Although the effect of common salts on the aqueous solubility of amino acids and proteins is phenomenologically well described [1], the underlying molecular-level mechanisms are far from being elucidated and consensual, in spite of the several explanations proposed during the past century.

Keywords

Molecular dynamics Solubility Amino acids Salts Measurement

URI

http://hdl.handle.net/10198/10524

Citation

Tomé, L.I.N.; Pinho, Simão; Jorge, M.; Gomes, J.R.B.; Coutinho, J.A.P. (2012). The cation effect on the aqueous solubility of amino acids in the presence of salts : experimental and molecular dynamics simulation studies. In InMother 2012. Lyon, France