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Realistic Aspects of Cardiac Ultrasound in Rats: Practical Tips for Improved Examination

2024Artigo científico Acesso aberto
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dc.contributor.authorSilva, Jessica
dc.contributor.authorGinja, Mário
dc.contributor.authorOliveira, Paula A.
dc.contributor.authorDuarte, José Alberto
dc.contributor.authorFaustino-Rocha, Ana
dc.date.accessioned2024-10-21T13:33:43Z
dc.date.available2024-10-21T13:33:43Z
dc.date.issued2024
dc.description.abstractEchocardiography is a reliable and non-invasive method for assessing cardiac structure and function in both clinical and experimental settings, offering valuable insights into disease progression and treatment efficacy. The successful application of echocardiography in murine models of disease has enabled the evaluation of disease severity, drug testing, and continuous monitoring of cardiac function in these animals. However, there is insufficient standardization of echocardiographic measurements for smaller animals. This article aims to address this gap by providing a guide and practical tips for the appropriate acquisition and analysis of echocardiographic parameters in adult rats, which may also be applicable in other small rodents used for scientific purposes, like mice. With advancements in technology, such as ultrahigh-frequency ultrasonic transducers, echocardiography has become a highly sophisticated imaging modality, offering high temporal and spatial resolution imaging, thereby allowing for real-time monitoring of cardiac function throughout the lifespan of small animals. Moreover, it allows the assessment of cardiac complications associated with aging, cancer, diabetes, and obesity, as well as the monitoring of cardiotoxicity induced by therapeutic interventions in preclinical models, providing important information for translational research. Finally, this paper discusses the future directions of cardiac preclinical ultrasound, highlighting the need for continued standardization to advance research and improve clinical outcomes to facilitate early disease detection and the translation of findings into clinical practice.pt_PT
dc.description.sponsorshipThis work was supported by national funds from the FCT—Portuguese Foundation for Science and Technology, under the projects UIDB/04033/2020 (CITAB, https://doi.org/10.544 99/UIDB/04033/2020), LA/P/0126/2020 (Inov4Agro, https://doi.org/10.54499/LA/P/0126/202 0), UIDB/00772/2020 (CECAV, https://doi.org/10.54499/UIDB/00772/2020), LA/P/0059/2020 (AL4AnimalS, https://doi.org/10.54499/LA/P/0059/2020), UIDB/00690/2020 (CIMO; https://doi. org/10.54499/UIDB/00690/2020), UIDP/00690/2020 (CIMO; https://doi.org/10.54499/UIDP/00 690/2020) and LA/P/0007/2020 (SusTEC; https://doi.org/10.54499/LA/P/0007/2020), and the doctoral grants awarded to J.S. (2020.07999.BD; https://doi.org/10.54499/2020.07999.BD) and T.A. (2023.01329.BD).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, Jessica; Azevedo, Tiago; Ginja, Mário; Oliveira, Paula A.; Duarte, José Alberto; Faustino-Rocha, Ana I. (2024). Realistic Aspects of Cardiac Ultrasound in Rats: Practical Tips for Improved Examination. Journal of Imaging. ISSN 2313-433X. 10:9, p. 1-31pt_PT
dc.identifier.doi10.3390/jimaging10090219pt_PT
dc.identifier.issn2313-433X
dc.identifier.urihttp://hdl.handle.net/10198/30464
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationCentre for the Research and Technology of Agro-Environmental and Biological Sciences
dc.relationInstitute for innovation, capacity building and sustainability of agri-food production
dc.relationVeterinary and Animal Science Research Centre
dc.relationAssociate Laboratory for Animal and Veterinary Sciences
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectEchocardiographypt_PT
dc.subjectMurine modelspt_PT
dc.subjectHeart functionpt_PT
dc.titleRealistic Aspects of Cardiac Ultrasound in Rats: Practical Tips for Improved Examinationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for the Research and Technology of Agro-Environmental and Biological Sciences
oaire.awardTitleInstitute for innovation, capacity building and sustainability of agri-food production
oaire.awardTitleVeterinary and Animal Science Research Centre
oaire.awardTitleAssociate Laboratory for Animal and Veterinary Sciences
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04033%2F2020/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0007%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/2020.07999.BD/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//2023.01329.BD/PT
oaire.citation.endPage31pt_PT
oaire.citation.issue9pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleJournal of Imagingpt_PT
oaire.citation.volume10pt_PT
oaire.fundingStream6817 - DCRRNI ID
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