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Evaluation of the composition in organic acids, vitamin E and phenolic compounds of lovage (Levisticum officinale W.D.J. Koch) roots

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dc.contributor.authorSprea, Rafael M.
dc.contributor.authorFernandes, Ângela
dc.contributor.authorFinimundy, Tiane C.
dc.contributor.authorCanan, Cristiane
dc.contributor.authorBarros, Lillian
dc.contributor.authorAmaral, Joana S.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2020-07-14T09:52:00Z
dc.date.available2020-07-14T09:52:00Z
dc.date.issued2019
dc.description.abstractSince ancient times, several aromatic plants and spices have been used worldwide in traditional medicine, in addition to its common usage for food purposes. Lovage (Levisticum officinale W.D.J. Koch) is an aromatic plant from the Apiaceae (Umbelliferae) family used as a condiment in several regions of Europe, being also described to have medicinal properties. In particular, lovage roots are described as possessing carminative and spasmolytic activity.1 According to the assessment report of the Committee on Herbal Medicinal Products (HMPC) of the European Medicines Agency on Levisticum officinale Koch, radix, this root is known as a medicine since ancient times in Greece, nowadays being authorized as a traditional herbal medicine in several countries of the European Union.2 This report also includes information regarding lovage root chemical composition, referring the presence of different phthalides, coumarines, phenylpropanoids (chlorogenic, caffeic and ferulic acids) and polyacetylenes (falcarindol and falcarinol). Apart from this information, the scientific literature reports mainly the chemical composition of the essential oil of lovage root, with no information being available regarding other bioactive compounds. Therefore, to address this gap, in this work, the organic acids, vitamin E and phenolic compounds of lovage roots were determined. Dried lovage roots were acquired from an herbal shop in Spain. Organic acids were determined by ultra-fast liquid chromatography coupled with a diode-array detector (Shimadzu Corporation, Japan) in the lyophilized sample, which was extracted using a methodology previously described and optimized.3 Tocopherols were determined in the lyophilized sample using a HPLC system coupled to a fluorescence detector as previously described.4 Phenolic compounds were analysed in two different extracts, namely hydroethanolic and decoction, after those being re-dissolved in ethanol/water (80:20, v/v) and water, respectively, to a concentration of 5 mg/mL. The compounds were evaluated using a Dionex Ultimate 3000 UPLC equipped with a quaternary pump and a diode array coupled in-series to an electrospray ionization mass spectrometry detector (LC-DAD-ESI/MSn) operating as previously described.5 The obtained results showed the presence of 3 organic acids in lovage root, namely oxalic (2.23±0.02 g/100 g d.w.), malic (1.48±0.04 g/100 g d.w.) and fumaric (0.007±0.001 g/100 g d.w.) and two tocopherols, α-tocopherol (0.83±0.03 mg/100 g d.w.) and γ -tocopherol (0.48±0.03 g/100 g d.w.). Regarding phenolic compounds’ composition, a total of 9 compounds, including phenolic acids and flavonoids, were identified and quantified, with vanilic acid being the predominant one in both types of extracts. Comparatively to the hydroethanolic extract, the decoction allowed the extraction of a significantly higher amount of total phenolic compounds (24,3±0,5 mg/g extract versus 3.07±0.04 mg/g extract). To our knowledge, this study represents the first report on the organic acids, vitamin E isoforms and phenolic compounds composition in lovage roots.pt_PT
dc.description.sponsorshipThe authors are grateful to FCT, Portugal and FEDER under Programme PT2020 for financial support to CIMO (UID/AGR/00690/2019); FEDER-Interreg España-Portugal programme for financial support through the project 0377_Iberphenol_6_E. L. Barros thanks the national funding by FCT, P.I., through the institutional scientific employment program-contract.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSpréa, Rafael Mascoloti; Fernandes, Ângela; Finimundy, Tiane C.; Canan, Cristiane; Barros, Lillian; Amaral, J.S.; Ferreira, Isabel C.F.R. (2019) Evaluation of the composition in organic acids, vitamin E and phenolic compounds of lovage (Levisticum officinale W.D.J. Koch) roots. In 11º Encontro Nacional de Cromatografia. Costa da Caparica. ISBN 978-989-8124-29-6pt_PT
dc.identifier.isbn978-989-8124-29-6
dc.identifier.urihttp://hdl.handle.net/10198/22472
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.titleEvaluation of the composition in organic acids, vitamin E and phenolic compounds of lovage (Levisticum officinale W.D.J. Koch) rootspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceCosta da Caparica, Portugalpt_PT
oaire.citation.title11º Encontro de Nacional de Cromatografiapt_PT
person.familyNameSprea
person.familyNameFernandes
person.familyNameFinimundy
person.familyNameBarros
person.familyNameAmaral
person.familyNameFerreira
person.givenNameRafael M.
person.givenNameÂngela
person.givenNameTiane C.
person.givenNameLillian
person.givenNameJoana S.
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id001F-273E-3A67
person.identifier.ciencia-id2015-0434-AE7C
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person.identifier.ciencia-id5319-7DE8-BEDA
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-0157-9873
person.identifier.orcid0000-0003-3516-0795
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-3648-7303
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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