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Can physical exercise modify intestinal integrity and gut microbiota composition? A systematic review of in vivo studies

2025Journal article Open access
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datacite.subject.fosCiências Sociais::Ciências da Educação
datacite.subject.fosCiências Naturais::Ciências Biológicas
datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg04:Educação de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
dc.contributor.authorPereira, Stephanie Michelin Santana
dc.contributor.authorSão José, Vinicius Parzanini Brilhante de
dc.contributor.authorSilva, Alessandra da
dc.contributor.authorMartins, Karina Vitoria Cipriana
dc.contributor.authorLeite , Luciano Bernardes
dc.contributor.authorForte, Pedro
dc.contributor.authorNatali, Antônio José
dc.contributor.authorMartino, Hércia Stampini Duarte
dc.contributor.authorLucia, Ceres Mattos Della
dc.contributor.authorBressan, Josefina
dc.date.accessioned2025-10-22T10:58:25Z
dc.date.available2025-10-22T10:58:25Z
dc.date.issued2025
dc.description.abstractThere is little evidence about how physical exercise affects the gut microbiota since studies in the field are relatively recent. Thus, we aimed to systematically review the main effects of regular physical exercise on the intestinal integrity and microbiota composition in animal models, discuss the mechanisms involved, and indicate future directions. Searches for original articles were performed in PubMed/MEDLINE, Scopus, Web of Science, and Embase. A total of 18 studies were selected. These studies suggest that physical exercise has a significant impact on the gut microbiota. Voluntary running increased the thickness of duodenal villi and microbiota diversity but reduced its richness. Low-intensity treadmill running increased the abundance of the phylum Actinobacteria and the family Bifidobacteriaceae, while that of moderate-intensity reduced the Bacteroides/Prevotella ratio. High-intensity swimming and treadmill running altered the gut microbiota, evidenced by beta-diversity, and increased the Shannon and Chao indices but reduced short-chain fatty acids. Resistance exercise increased the Chao index and altered the functionality of the gut microbiota, increasing carbohydrate metabolism and reducing lipid and amino acid metabolism. Thus, regular physical exercise of different intensities and types can modify the gut microbiota, and the exercise benefits appear to be positively associated with training intensity.eng
dc.description.sponsorshipWe would like to express our gratitude to the funding agencies CAPES (001), CNPq and FAPEMIG (APQ-04073-23) for supporting research, development and innovation activities, and granting scholarships.
dc.identifier.citationPereira, Stephanie Michelin Santana; São José, Vinicius Parzanini Brilhante de; Silva, Alessandra da; Martins, Karina Vitoria Cipriana; Leite, Luciano Bernardes; Forte, Pedro; Natali, Antônio José; Martino, Hércia Stampini Duarte; Lucia, Ceres Mattos Della; Bressan, Josefina (2025) Can physical exercise modify intestinal integrity and gut microbiota composition? A systematic review of in vivo studies. Biology of Sport. ISSN 0860-021X. 42:4, p. 13-28
dc.identifier.doi10.5114/biolsport.2025.148545
dc.identifier.issn0860-021X
dc.identifier.urihttp://hdl.handle.net/10198/34860
dc.language.isoeng
dc.peerreviewedyes
dc.publisherInstitute of Sport
dc.relation.ispartofBiology of Sport
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectMicrobiome
dc.subjectMicrobial community
dc.subjectCompositions
dc.subjectPhysical activity
dc.subjectTraining
dc.titleCan physical exercise modify intestinal integrity and gut microbiota composition? A systematic review of in vivo studieseng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage28
oaire.citation.issue4
oaire.citation.startPage13
oaire.citation.titleBiology of Sports
oaire.citation.volume42
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameLeite
person.familyNameForte
person.givenNameLuciano Bernardes
person.givenNamePedro
person.identifier.ciencia-id351B-B16B-79C7
person.identifier.orcid0000-0002-3012-1327
person.identifier.orcid0000-0003-0184-6780
relation.isAuthorOfPublication4c072c63-1f8c-4b53-9373-e2ab0b754c31
relation.isAuthorOfPublication3ecc6d1b-07a4-40d7-81f4-df6fd7b3d5b0
relation.isAuthorOfPublication.latestForDiscovery3ecc6d1b-07a4-40d7-81f4-df6fd7b3d5b0

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