Advisor(s)
Abstract(s)
A library of C3–C5 unsaturated 6-O-sucrose
esters have been investigated for their antibacterial, antifungal,
and cytotoxic activities. Most of the target compounds
showed good inhibitory activity against a variety of
clinically and food contaminant important microbial
pathogens. In particular, 6-O-methacryloyl sucrose 2 and
1′,2,3,3′,4,4′,6′-hepta-O-acetyl-6-O-methacryloyl sucrose 9
were the most active bactericides against all the tested
bacteria with minimal inhibitory concentrations (MICs)
ranging between 0.24 and 1.40 μM. The compound 9
showed also the highest antifungal activity with MICs from
0.28 to 1.10 μM. The synthesized compounds possessed
low cytotoxicity against human breast, lung, cervical, and
hepatocellular carcinoma cell lines without showing toxicity
for non-tumor liver cells. Thus, this library of short carbon
chain unsaturated sucrose esters represent promising leads
for the development of new generation of sucrose-based
antimicrobial agents.
Description
Keywords
Antibacterial activity Antifungal activity Cytotoxic activity Sucrose Unsaturated esters
Pedagogical Context
Citation
Petrova, Krasimira T.; Barros, M. Teresa; Calhelha, Ricardo C.; Soković, Marina; Ferreira, Isabel C.F.R. (2018). Antimicrobial and cytotoxic activities of short carbon chain unsaturated sucrose esters. Medicinal Chemistry Research. ISSN 1054-2523. 27, p. 980-988