Publication
The Role of Gut Microbiota in the Etiopathogenesis of Multiple Chronic Diseases
| dc.contributor.author | Pires, Lara | |
| dc.contributor.author | González-Paramás, Ana María | |
| dc.contributor.author | Heleno, Sandrina A. | |
| dc.contributor.author | Calhelha, Ricardo C. | |
| dc.date.accessioned | 2024-06-11T15:58:53Z | |
| dc.date.available | 2024-06-11T15:58:53Z | |
| dc.date.issued | 2024 | |
| dc.description.abstract | Chronic diseases (CD) may result from a combination of genetic factors, lifestyle and social behaviours, healthcare system influences, community factors, and environmental determinants of health. These risk factors frequently coexist and interact with one another. Ongoing research and a focus on personalized interventions are pivotal strategies for preventing and managing chronic disease outcomes. A wealth of literature suggests the potential involvement of gut microbiota in influencing host metabolism, thereby impacting various risk factors associated with chronic diseases. Dysbiosis, the perturbation of the composition and activity of the gut microbiota, is crucial in the etiopathogenesis of multiple CD. Recent studies indicate that specific microorganism-derived metabolites, including trimethylamine N-oxide, lipopolysaccharide and uremic toxins, contribute to subclinical inflammatory processes implicated in CD. Various factors, including diet, lifestyle, and medications, can alter the taxonomic species or abundance of gut microbiota. Researchers are currently dedicating efforts to understanding how the natural progression of microbiome development in humans affects health outcomes. Simultaneously, there is a focus on enhancing the understanding of microbiome-host molecular interactions. These endeavours ultimately aim to devise practical approaches for rehabilitating dysregulated human microbial ecosystems, intending to restore health and prevent diseases. This review investigates how the gut microbiome contributes to CD and explains ways to modulate it for managing or preventing chronic conditions. | pt_PT |
| dc.description.sponsorship | The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support by national funds FCT/MCTES CIMO (UIDB/00690/2020 and UIDP/00690/2020) and SusTEC (LA/P/0007/2020); national funding by FCT, P.I., through the institutional scientific employment program-contract for S.Heleno and R. Calhelha contracts. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Pires, Lara; González-Paramás, Ana M.; Heleno, Sandrina A.; Calhelha, Ricardo C. (2024). The Role of Gut Microbiota in the Etiopathogenesis of Multiple Chronic Diseases. Antibiotics. ISSN 2079-6382. 13:5, p. 1-27 | pt_PT |
| dc.identifier.doi | 10.3390/antibiotics13050392 | pt_PT |
| dc.identifier.issn | 2079-6382 | |
| dc.identifier.uri | http://hdl.handle.net/10198/29879 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | MDPI | pt_PT |
| dc.relation | Mountain Research Center | |
| dc.relation | Mountain Research Center | |
| dc.relation | Associate Laboratory for Sustainability and Tecnology in Mountain Regions | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Chronic diseases | pt_PT |
| dc.subject | Gut microbiota | pt_PT |
| dc.subject | Dysbiosis | pt_PT |
| dc.title | The Role of Gut Microbiota in the Etiopathogenesis of Multiple Chronic Diseases | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | Mountain Research Center | |
| oaire.awardTitle | Mountain Research Center | |
| oaire.awardTitle | Associate Laboratory for Sustainability and Tecnology in Mountain Regions | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0007%2F2020/PT | |
| oaire.citation.endPage | 27 | pt_PT |
| oaire.citation.issue | 5 | pt_PT |
| oaire.citation.startPage | 1 | pt_PT |
| oaire.citation.title | Antibiotics | pt_PT |
| oaire.citation.volume | 13 | pt_PT |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| person.familyName | Heleno | |
| person.familyName | Calhelha | |
| person.givenName | Sandrina A. | |
| person.givenName | Ricardo C. | |
| person.identifier.ciencia-id | 8B18-3095-6FC9 | |
| person.identifier.ciencia-id | F313-E3CE-554E | |
| person.identifier.orcid | 0000-0001-7224-1098 | |
| person.identifier.orcid | 0000-0002-6801-4578 | |
| person.identifier.rid | L-5951-2014 | |
| person.identifier.rid | J-2172-2014 | |
| person.identifier.scopus-author-id | 30067731800 | |
| person.identifier.scopus-author-id | 6507978333 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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