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Bioactives of the essential oil from the leaves of Eugenia pyriformis Cambess (Myrtaceae) on the effects of tobacco

2024Journal article Open access
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dc.contributor.authorMedeiros, Jaqueline Pavelegini de
dc.contributor.authorRodrigues, Selma Alves
dc.contributor.authorSakumoto, Karina
dc.contributor.authorRuiz, Suelen Pereira
dc.contributor.authorFaria, Maria Graciela Iecher
dc.contributor.authorGonçalves, José Eduardo
dc.contributor.authorPiau Junior, Ranulfo
dc.contributor.authorGlamočlija, Jasmina
dc.contributor.authorSoković, Marina
dc.contributor.authorGonçalves, Daniela Dib
dc.contributor.authorMandim, Filipa
dc.contributor.authorBarros, Lillian
dc.contributor.authorGazim, Zilda Cristiani
dc.date.accessioned2024-07-22T13:07:05Z
dc.date.available2024-07-22T13:07:05Z
dc.date.issued2024
dc.description.abstractLung cancer is the most commonly diagnosed and the main cause of cancer death, usually related to cigarette smoking. Furthermore, the microbiota of people exposed to cigarette smoke can be modified, making it difficult to eliminate opportunistic microorganisms. The leaves of Eugenia pyriformis are a by-product of fruit production and, to date, there have been no studies addressing the antiproliferative, anti-inflammatory, and antimicrobial activities. Objective Investigate the antimicrobial, Nitric Oxide (NO)-production inhibition, and antiproliferative activities of the essential oil from E. pyriformis leaves and its possible effect on the treatment and prevention of damage caused by tobacco. Methods The essential oil (EO) was obtained by hydrodistillation (3 h). Its chemical composition was investigated by GC-MS. It was proposed to investigate antiproliferative activity against human tumor cell lines, namely, breast adenocarcinoma (MCF-7), lung (NCI-H460), cervical (HeLa), and hepatocellular (HepG2) carcinomas. A non-tumor primary culture from pig liver (PLP2) was also tested. The EO capacity to inhibit nitric oxide (NO) production was evaluated by a lipopolysaccharide stimulated murine macrophage cell line. Antibacterial and antifungal activities against opportunistic pathogens were investigated against seven strains of bacteria and eight fungi. Results The results indicated the presence of 23 compounds in the essential oil, the majority were spathulenol (45.63%) and beta-caryophyllene oxide (12.72%). Leaf EO provided 50% inhibition of nitric oxide production at a concentration of 92.04 mu g mL(-1). The EO also demonstrated antiproliferative activity against all human tumor cell lines studied, with GI50 values comprised between 270.86 and 337.25 mu g mL(-1). The essential oil showed antimicrobial potential against the bacteria Listeria monocytogenes (Murray et al.) Pirie (NCTC 7973) and Salmonella Typhimurium ATCC 13311 (MIC 1870 mu g mL(-1)) and fungi Aspergillus versicolor ATCC 11730, Aspergillus ochraceus ATCC 12066, Penicillium ochrochloron ATCC 90288, Penicillium verrucosum var. cyclopium (Westling) Samson, Stolk & Hadlok (food isolate) (MIC 1870 mu g mL(-1)) and Trichoderma viride Pers. IAM 5061 (1,400 mu g mL(-1)). Conclusion The demonstrated anti-inflammatory, antiproliferative, and antimicrobial activities in the leaves of E. pyriformis can add value to the production chain of this plant, being a possible option for preventing and combating cancer, including lung cancer.pt_PT
dc.description.sponsorshipThe authors declare financial support was received for the research, authorship, and/or publication of this article. The authors thank Universidade Paranaense (Finance code 36902/2020), UniCesumar, this work was supported by national funds through FCT/MCTES (PIDDAC): CIMO, UIDB/00690/2020 (DOI: 10.54499/UIDB/00690/2020) and UIDP/00690/2020 (DOI: 10.54499/UIDP/00690/2020); and SusTEC, LA/P/0007/2020 (DOI: 10.54499/LA/P/0007/2020); national funding by FCT, P.I., through the institutional scientific employment program-contract for LB contrato. Coordenac & atilde;o de Aperfeicoamento de Pessoal de Nivel Superior-Brazil (CAPES) -finance code 001-, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), and Fundac & atilde;o Araucaria for the financial support and the fellowship. Ministry of Education, Science and Technological Development of the Republic of Serbia (grant number: 451-03-66/2024-03/ 200007).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMedeiros, Jaqueline Pavelegini de; Rodrigues, Selma Alves; Sakumoto, Karina; Ruiz, Suelen Pereira; Faria, Maria Graciela Iecher; Gonçalves, José Eduardo; Piau Junior, Ranulfo; Glamočlija, Jasmina; Soković, Marina; Gonçalves, Daniela Dib; Mandim, Filipa; Barros, Lillian; Gazim, Zilda Cristiani (2024). Bioactives of the essential oil from the leaves of Eugenia pyriformis Cambess (Myrtaceae) on the effects of tobacco. Frontiers in Pharmacology. ISSN 1663-9812. 15, p. 1-11pt_PT
dc.identifier.doi10.3389/fphar.2024.1415659pt_PT
dc.identifier.eissn1663-9812
dc.identifier.issn1663-9812
dc.identifier.urihttp://hdl.handle.net/10198/30058
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectLung carcinomapt_PT
dc.subjectAntiproliferativept_PT
dc.subjectUvaiapt_PT
dc.subjectNitric oxidept_PT
dc.subjectAntimicrobial activitypt_PT
dc.subjectβ- caryophyllene oxidept_PT
dc.subjectSpathulenolpt_PT
dc.titleBioactives of the essential oil from the leaves of Eugenia pyriformis Cambess (Myrtaceae) on the effects of tobaccopt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0007%2F2020/PT
oaire.citation.endPage11pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleFrontiers in Pharmacologypt_PT
oaire.citation.volume15pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMandim
person.familyNameBarros
person.givenNameFilipa
person.givenNameLillian
person.identifier469085
person.identifier.ciencia-idF318-9049-EB99
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0002-6494-2326
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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