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Resumo(s)
Chromones and xanthones are oxygen-containing heterocyclic compounds with bioactive
properties widely reported in the literature, specially concerning to their antioxidant
properties. The search for new natural and synthetic chromone and xanthone derivatives order
to evaluate and discover new structural features rendering optimized biological effects has
been a challenge. Thus, the aim of this work was to evaluate the scavenging activity of
reactive oxygen (ROS) and nitrogen (RNS) species of new synthetic hydroxylated chromones
and xanthones (Fig. 1) using in vitro non-cellular systems. These compounds exhibited
scavenger effects dependent on the concentration, with IC50 values found at the micromolar
range. The overall scavenging activity of chromones was better than xanthones, specially the
one of chromone 3A. In conclusion, the novel tested chromone and xanthone scaffolds proved
to be promising pharmacophores with potential therapeutic applications as antioxidant agents.
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Contexto Educativo
Citação
Proença, Carina; Ribeiro, Daniela; Freitas, Marisa; Albuquerque, Hélio; Santos, Clementina M.M.; Silva, Artur; Fernandes, Eduarda (2015). The antioxidant activity of novel chromones and xanthones: a structure-activity relationship. In XXI Encontro Galego-Português de Química. Pontevedra. ISBN 978‐84‐608‐3441‐0
Editora
Colegio Oficial de Químicos de Galicia