Assessment of plant food supplements adulteration with psychopharmaceutical drugs

Rodrigues, Manuela J.E.; Paíga, Paula; Santos, Lúcia H.M.L.M.; Amaral, Joana S.; Oliveira, Beatriz; Correia, Manuela; Delerue-Matos, Cristina

Publication

Assessment of plant food supplements adulteration with psychopharmaceutical drugs

2015Conference object

dc.contributor.author	Rodrigues, Manuela J.E.
dc.contributor.author	Paíga, Paula
dc.contributor.author	Santos, Lúcia H.M.L.M.
dc.contributor.author	Amaral, Joana S.
dc.contributor.author	Oliveira, Beatriz
dc.contributor.author	Correia, Manuela
dc.contributor.author	Delerue-Matos, Cristina
dc.date.accessioned	2018-04-04T10:25:14Z
dc.date.available	2018-04-04T10:25:14Z
dc.date.issued	2015
dc.description.abstract	The purpose of this study was to compare three different extraction methods (two based on ethanol extraction and one on the Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERs) method) to assess the possible addition of psychopharmaceutical drugs (fluoxetine, sertraline, citalopram, venlafaxine, paroxetine, trazodone, and diazepam) as adulterants in St. John's wort (Hypericum perforatum) based plant food supplements (PFS). Methodology: Analysis was performed in a Nexera Ultra-High Performance Liquid Chromatograph (UHPLC) coupled to a triple-quadrupole mass spectrometer (LCMS-8030 Shimadzu) with an electrospray ionization source (ESI), operating in positive ion mode, using a Kinetex C18 fused core column (150 × 2.10 mm i.d.; 1.7 m) (Phenomenex). Multiple reaction monitoring mode (MRM) was selected and pharmaceuticals were quantified by internal standard calibration method. Calibration curves were constructed in the range 10 – 1000 g/L. The three different extraction methods were compared based on the analysis of spiked samples.	pt_PT
dc.description.sponsorship	This work received financial support from the European Union (FEDER funds through COMPETE) and National Funds (FCT, Fundação para a Ciência e Tecnologia) through project EXPL/DTP-SAP/1438/2013 and Pest- C/EQB/LA0006/2013. To all financing sources the authors are greatly indebted.	pt_PT
dc.description.version	info:eu-repo/semantics/publishedVersion	pt_PT
dc.identifier.citation	Rodrigues, Manuela J.E.; Paíga, Paula; Santos, Lúcia H.M.L.M.; Amaral, J.S.; Oliveira, M.B.P.P.; Correia, Manula; Delerue-Matos, Cristina (2015) . Assessment of plant food supplements adulteration with psychopharmaceutical drugs. In International Conference on Food Contaminants - ICFC 2015. Lisboa
dc.identifier.uri	http://hdl.handle.net/10198/16663
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.title	Assessment of plant food supplements adulteration with psychopharmaceutical drugs	pt_PT
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oaire.awardURI	info:eu-repo/grantAgreement/FCT/COMPETE/EXPL%2FDTP-SAP%2F1438%2F2013/PT
oaire.awardURI	info:eu-repo/grantAgreement/FCT/COMPETE/PEst-C%2FEQB%2FLA0006%2F2013/PT
oaire.citation.conferencePlace	Lisbon, Portugal	pt_PT
oaire.citation.endPage	86	pt_PT
oaire.citation.startPage	85	pt_PT
oaire.citation.title	International Conference on Food Contaminants - ICFC 2015	pt_PT
oaire.fundingStream	COMPETE
oaire.fundingStream	COMPETE
person.familyName	Amaral
person.givenName	Joana S.
person.identifier.ciencia-id	5319-7DE8-BEDA
person.identifier.orcid	0000-0002-3648-7303
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.name	Fundação para a Ciência e a Tecnologia
project.funder.name	Fundação para a Ciência e a Tecnologia
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