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Resumo(s)
The purpose of this study was to compare three different
extraction methods (two based on ethanol extraction and one on the Quick,
Easy, Cheap, Effective, Rugged, and Safe (QuEChERs) method) to assess the
possible addition of psychopharmaceutical drugs (fluoxetine, sertraline,
citalopram, venlafaxine, paroxetine, trazodone, and diazepam) as
adulterants in St. John's wort (Hypericum perforatum) based plant food
supplements (PFS).
Methodology: Analysis was performed in a Nexera Ultra-High Performance
Liquid Chromatograph (UHPLC) coupled to a triple-quadrupole mass
spectrometer (LCMS-8030 Shimadzu) with an electrospray ionization source
(ESI), operating in positive ion mode, using a Kinetex C18 fused core column
(150 × 2.10 mm i.d.; 1.7 m) (Phenomenex). Multiple reaction monitoring
mode (MRM) was selected and pharmaceuticals were quantified by internal
standard calibration method. Calibration curves were constructed in the
range 10 – 1000 g/L. The three different extraction methods were
compared based on the analysis of spiked samples.
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Citação
Rodrigues, Manuela J.E.; Paíga, Paula; Santos, Lúcia H.M.L.M.; Amaral, J.S.; Oliveira, M.B.P.P.; Correia, Manula; Delerue-Matos, Cristina (2015) . Assessment of plant food supplements adulteration with psychopharmaceutical drugs. In International Conference on Food Contaminants - ICFC 2015. Lisboa