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Firefighters’ exposure biomonitoring: Impact of firefighting activitieson levels of urinary monohydroxyl metabolites

2016Journal article Open access
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dc.contributor.authorOliveira, Marta
dc.contributor.authorSlezakova, Klara
dc.contributor.authorAlves, Maria José
dc.contributor.authorFernandes, Adília
dc.contributor.authorTeixeira, João Paulo Fernandes
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorPereira, Maria do Carmo
dc.contributor.authorMorais, Simone
dc.date.accessioned2016-11-21T17:11:03Z
dc.date.available2016-11-21T17:11:03Z
dc.date.issued2016
dc.description.abstracttThe concentrations of six urinary monohydroxyl metabolites (OH-PAHs) of polycyclic aro-matic hydrocarbons, namely 1-hydroxynaphthalene, 1-hydroxyacenaphthene, 2-hydroxyfluorene,1-hydroxyphenanthrene, 1-hydroxypyrene (1OHPy), and 3-hydroxybenzo[a]pyrene, were assessed inthe post-shift urine of wildland firefighters involved in fire combat activities at six Portuguese firecorporations, and compared with those of non-exposed subjects. Overall, median levels of urinaryindividual and total OH-PAHs ( OH-PAHs) suggest an increased exposure to polycyclic aromatic hydro-carbons during firefighting activities with OH-PAH levels in exposed firefighters 1.7–35 times higherthan in non-exposed ones. Urinary 1-hydroxynaphthalene and/or 1-hydroxyacenapthene were the pre-dominant compounds, representing 63–98% of OH-PAHs, followed by 2-hydroxyfluorene (1–17%),1-hydroxyphenanthrene (1–13%), and 1OHPy (0.3–10%). A similar profile was observed when gen-der discrimination was considered. Participation in fire combat activities promoted an increase of thedistribution percentage of 1-hydroxynaphthalene and 1-hydroxyacenaphthene, while contributions of1-hydroxyphenanthrene and 1OHPy decreased. The detected urinary 1OHPy concentrations (1.73 × 10−2to 0.152 mol/mol creatinine in exposed subjects versus 1.21 × 10−2to 5.44 × 10−2 mol/mol creatininein non-exposed individuals) were lower than the benchmark level (0.5 mol/mol creatinine) proposedby the American Conference of Governmental Industrial Hygienists. This compound, considered thebiomarker of exposure to PAHs, was the less abundant one from the six analyzed biomarkers. Thusthe inclusion of other metabolites, in addition to 1OHPy, in future studies is suggested to better estimatefirefighters’ occupational exposure to PAHs. Moreover, strong to moderate Spearman correlations wereobserved between individual compounds and OH-PAHs corroborating the prevalence of an emissionsource.pt_PT
dc.identifier.citationOliveira, M.; Slezakova, K.; Alves, Maria José; Fernandes, Adília; Teixeira, J.P.,Delerue-Matos, C.; Pereira, M.C., Morais, S. (2016). Firefighters’ exposure biomonitoring: Impact of firefighting activitieson levels of urinary monohydroxyl metabolites. International Journal of Hygiene and Environmental Health, ISSN 1438-4639. p. 857-866pt_PT
dc.identifier.issn1438-4639
dc.identifier.urihttp://hdl.handle.net/10198/13518
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectWildland firefighterspt_PT
dc.subjectOccupational exposurept_PT
dc.subjectPolycyclic aromatic hydrocarbonspt_PT
dc.subjectBiomarkers of exposurept_PT
dc.subjectUrinary monohydroxyl metabolitesaitespt_PT
dc.titleFirefighters’ exposure biomonitoring: Impact of firefighting activitieson levels of urinary monohydroxyl metabolitespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage866pt_PT
oaire.citation.startPage857pt_PT
oaire.citation.titleInternational Journal of Hygiene and Environmental Healthpt_PT
person.familyNameAlves
person.familyNameFernandes
person.givenNameMaria José
person.givenNameAdília
person.identifier.ciencia-idD618-B3A9-D312
person.identifier.ciencia-id0514-76CD-8CCF
person.identifier.orcid0000-0001-8506-4393
person.identifier.orcid0000-0003-1658-4509
person.identifier.ridM-6624-2016
person.identifier.ridV-8399-2017
person.identifier.scopus-author-id16400584800
person.identifier.scopus-author-id56489572200
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication7850f8c2-8834-4d5a-b4a7-df482abd76d3
relation.isAuthorOfPublicationbdfceda8-18d6-4b63-b6f9-d3870cd0dbb0
relation.isAuthorOfPublication.latestForDiscovery7850f8c2-8834-4d5a-b4a7-df482abd76d3

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