Publication
Tomato glycoalkaloids as new drug candidates: an overview of mechanisms of action and clinicai applications
| dc.contributor.author | Pinela, José | |
| dc.contributor.author | Oliveira, Beatriz | |
| dc.contributor.author | Ferreira, Isabel C.F.R. | |
| dc.date.accessioned | 2019-01-08T11:13:48Z | |
| dc.date.available | 2019-01-08T11:13:48Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | Glycoalkaloids are characteristic secondary metabolites in plants of the Solanaceae family. Although perceived as potentially toxic, these compounds display different bioactivities and pharmacological efFects. The glycoalkaloid tomatine can be found in green tomatoes and comprises a junction ofa-tomatine (A) and dehydrotomatine (B). As shown in Figure l, dehydrotomatine difFers from a-tomatine by having a double bond in the steroidal B ring of the aglycone; but both glycoalkaloids have the same tetrasaccharide (lycotetraose) side chain. Therefore, while a-tomatine hás lycotetraose bonded to the aglycone tomatidine, dehydrotomatine hás the side chain attached to the aglycone tomatidenol. Up to 500 mg/kg of tomatine can be found in unripe (green) tomatoes, leveis that decrease with ripening (approximately 5 mg/kg in ripe red tomatoes) [l]. We revised the mechanisms of action of tomatine and their involvement in human health [l]. Its bioactivity derives mainly from the capacity to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) and to complex with membrane 3j8-hydroxy sterols. In inflammatory processes, the aglycone tomatidine is able to reduce inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression through blocking nuclear factor kappa B (NF-KB) and c-Jun N-terminal kinase (JNK) signalling in lipopolysaccharide-stimulated macrophages. In turn, a-tomatine hás the ability to decrease the cholesterol and triglyceride leveis, enhance tUe immune system, and inhibit the growth of diíFerent type of câncer cells. Several in vitro and in vivo studies have been highlighting the pharmacological potential of these compounds, which have high potential to be used in the development of new anticancer drugs, among others. | pt_PT |
| dc.description.sponsorship | To FCT (Portugal) and FEDER under Programme PT2020 for financiai support to CIMO (UID/AGR/00690/2013) and REQUIMTE/LAQV (UID/QUI/50006/2013 - POCI/01/0145/ FEDER/007265) and the research contract (Project AllNatt, POCI-01-0145-FEDER-030463) ofj. Pinela. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Pinela, José; Oliveira, M.B.P.P.; Ferreira, Isabel C.F.R. (2018). Tomato glycoalkaloids as new drug candidates: an overview of mechanisms of action and clinicai applications. In XXIV Encontro Luso Galego de Química. Porto. ISBN 978-989-8124-24-1 | pt_PT |
| dc.identifier.isbn | 978-989-8124-24-1 | |
| dc.identifier.uri | http://hdl.handle.net/10198/18319 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Tomato glycoalkaloids | pt_PT |
| dc.title | Tomato glycoalkaloids as new drug candidates: an overview of mechanisms of action and clinicai applications | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F00690%2F2013/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F50006%2F2013/PT | |
| oaire.citation.conferencePlace | Porto, Portugal | pt_PT |
| oaire.citation.title | XXIV Encontro Luso Galego de Química | pt_PT |
| oaire.fundingStream | 5876 | |
| oaire.fundingStream | 5876 | |
| person.familyName | Pinela | |
| person.familyName | Ferreira | |
| person.givenName | José | |
| person.givenName | Isabel C.F.R. | |
| person.identifier | 144781 | |
| person.identifier.ciencia-id | 771C-2B43-B108 | |
| person.identifier.ciencia-id | 9418-CF95-9919 | |
| person.identifier.orcid | 0000-0001-7523-1637 | |
| person.identifier.orcid | 0000-0003-4910-4882 | |
| person.identifier.rid | B-4466-2014 | |
| person.identifier.rid | E-8500-2013 | |
| person.identifier.scopus-author-id | 54392272800 | |
| person.identifier.scopus-author-id | 36868826600 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |
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