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Loss of quality of corneas stored in hypothermic preservation media during processing and evaluation in an eye bank: a cohort study

2026Artigo científico Acesso aberto
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg04:Educação de Qualidade
dc.contributor.authorMota, Felipe Machado
dc.contributor.authorJúnior, Marcos Antonio Ferreira
dc.contributor.authorHilgert, Christiana Velloso Rebello
dc.contributor.authorFrota, Oleci Pereira
dc.contributor.authorAzevedo, Isabelle Campos
dc.contributor.authorSantos, Viviane Euzébia Pereira
dc.contributor.authorMartins, Matilde
dc.contributor.authorMaidana, Gustavo Moura
dc.contributor.authorMenezes, Bethânia Karoline Alvaro
dc.contributor.authorAbes, Bruna Dias
dc.contributor.authorBorges, Sara Raquel Pinto
dc.contributor.authorNeves, Guilherme Parreira
dc.date.accessioned2026-07-30T14:36:18Z
dc.date.available2026-07-30T14:36:18Z
dc.date.issued2026
dc.description.abstractThis study aimed to analyze factors associated with the loss of quality of corneas stored in hypothermic preservation media during processing and evaluation in an eye bank. A cohort study was conducted using records from 422 donors (844 corneas) between January 1, 2022, and March 31, 2024. Corneal quality was determined through slit-lamp biomicroscopy based on 13 morphological criteria, with tissues classified on a Likert-type scale from 0 (excellent) to 4 (unacceptable). For analysis, corneas were grouped as higher quality (scores 0–2: excellent, good, and fair) and lower quality (scores 3–4: poor and unacceptable). The outcome was defined as progression from higher to lower quality between the first and second evaluations. No statistically significant associations were found between donor clinical or sociodemographic variables and progression to lower quality. The relative risk (RR) of progression to the lower-quality group according to the storage medium (Optisol-GS vs Eusol-C) was low, RR 1.01 (95% Confidence Interval: 0.94 – 1.07), possibly due to the short interval between evaluations (≤ 4 days). However, a significant trend toward higher scores was observed during the second evaluation. These findings suggest that donor characteristics, processing factors, and the preservation medium did not significantly influence the deterioration of corneal quality within the analyzed period. The differences observed between the evaluations are possibly related to the subjective nature of slit-lamp assessment rather than true tissue degradation.por
dc.identifier.citationMota, Felipe Machado; Júnior, Marcos Antonio Ferreira; Hilgert, Christiana Velloso Rebello; Frota, Oleci Pereira; Azevedo, Isabelle Campos; Santos, Viviane Euzébia Pereira; Martins, Matilde; Maidana, Gustavo Moura; Menezes, Bethânia Karoline Alvaro; Abes, Bruna Dias; Borges, Sara Raquel Pinto; Neves, Guilherme Parreira (2026). Loss of quality of corneas stored in hypothermic preservation media during processing and evaluation in an eye bank: a cohort study. Cell and Tissue Bank. ISSN 1389-9333. p. 1-15
dc.identifier.doi/10.1007/s10561-026-10240-4
dc.identifier.issn1389-9333
dc.identifier.urihttp://hdl.handle.net/10198/37061
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer Nature
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectEye banks
dc.subjectCorneal transplantation
dc.subjectEpidemiology
dc.titleLoss of quality of corneas stored in hypothermic preservation media during processing and evaluation in an eye bank: a cohort studyeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage15
oaire.citation.startPage1
oaire.citation.titleCell and Tissue Bank
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameMartins
person.givenNameMatilde
person.identifier.ciencia-id8512-BB32-73C5
person.identifier.orcid0000-0003-2656-5897
person.identifier.scopus-author-id55293441900
relation.isAuthorOfPublication8a357d2f-d378-430e-a3cd-007922f1a068
relation.isAuthorOfPublication.latestForDiscovery8a357d2f-d378-430e-a3cd-007922f1a068

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