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Advisor(s)
Abstract(s)
Chromones is a family of oxygen heterocyclic compounds whose synthetic versatility
and broad spectrum of bioactive properties has been widely reported over the
past decade. The increasing number of publications related to the synthesis of this
heterocyclic system highlights diverse synthetic approaches, using different starting
materials, with novel and efficient synthetic details, applying alternative heating conditions,
that provides a huge number of polyfunctionalized 4H-chromen-4-one derivatives.
The purpose of this chapter is to present a comprehensive survey of the methodologies
developed for the synthesis of 2,3-unsubstituted, 2- and 3-substituted and
2,3-disubstituted 4H-chromen-4-ones, focusing on the literature since 2012, in nearly
450 publications.
Description
Keywords
Acetophenone Aldol condensation Baker-Venkataraman Chalcone Chromone Cyclodehydration Enaminone Flavone Isoflavone Multicomponent reaction
Citation
Santos, Clementina M.M.; Silva, Artur (2022). Recent advances in the synthesis of 4H-chromen-4-ones (2012 − 2021). In Advances in Heterocyclic Chemistry. Vol. 138, p. 159-241. ISBN 978-032398859-9
Publisher
Elsevier