Dietary compounds that modify bilirubin levels

Pereira, Rosa; Monteiro, Sandrine; Rodrigues, Carina; Vaz, Josiana A.; Ferreira, Isabel C.F.R.

Publication

Dietary compounds that modify bilirubin levels

2016Conference object

dc.contributor.author	Pereira, Rosa
dc.contributor.author	Monteiro, Sandrine
dc.contributor.author	Rodrigues, Carina
dc.contributor.author	Vaz, Josiana A.
dc.contributor.author	Ferreira, Isabel C.F.R.
dc.date.accessioned	2017-01-17T15:38:46Z
dc.date.available	2017-01-17T15:38:46Z
dc.date.issued	2016
dc.description.abstract	Bilirubin (BL) is a bile pigment that arises from the catabolism of hemeproteins and it is an important biochemical marker for diagnosis and monitoring of hepatic and hematologic diseases. The high concentration of this metabolite in plasma may be associated with disturbances in production, metabolism and/or excretion. Several in vivo in vitro studies have established the antioxidant, anti-inflammatory and anti-tumoral bilirubin capacity. The main objective was to verify that the effects of certain drugs and nutritional compounds on the metabolism of bilirubin, as well as studying the effects of radical substances in the UGT1A1 gene in addition have also studied the effect of various enzymes on serum bilirubin. The methodology was a detailed search online database, such as Pubmed, NCBI, ScienceDirect and books, a five-month period. Several studies refer four botanical groups as associated to changes in bilirubin concentrations Cruciferae (e.g., broccoli), Rutaceae (citrus), Liliaceae (e.g., onions), and Leguminosae (legumes). In a hyperbilirubinemic condition, the best approach would include the increasing UGT1A1 expression and this can be achieved with foods from the botanical families Cruciferae, Rutaceae, Liliaceae, and Leguminosae. Regulation of UGTs by phytochemicals has been investigated with a focus on cancer prevention numerous inhibitors from plant origin. The strategy to rise SBL, inhibiting UGT1A1 activity appears unreasonable. Several studies show that low serum bilirubin concentrations are associated with an increased risk of chronic diseases, whereas slightly elevated serum bilirubin levels seems to provide protection. The enzymes HO-1 and BLV will also have an important role in the development of therapeutic strategies based on dietary compounds however for these two enzymes there was considerable less information about their inducers and inhibitors. It is proven that the ingestion of certain foods affects the metabolism of bilirubin and the expression of UGT1A1 gene. Thus, it is justified the need for further studies to demonstrate the potential of food to control the maintenance of bilirubin in order to identify possible functional foods.	pt_PT
dc.description.version	info:eu-repo/semantics/publishedVersion	pt_PT
dc.identifier.citation	Pereira, Rosa; Monteiro, Sandrine; Rodrigues, Carina; Vaz, Josiana A.; Ferreira, Isabel C.F.R. (2016). Dietary compounds that modify bilirubin levels. In I Congresso Nacional \| I Encontro Nacional de Estudantes Ciências Biomédicas Laboratoriais: Livro de Resumos. Bragança. ISBN 978-972-745-211-8. p. 46-46	pt_PT
dc.identifier.isbn	978-972-745-211-8
dc.identifier.uri	http://hdl.handle.net/10198/13846
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Instituto Politécnico de Bragança, Escola Superior de Saúde	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	Bilirubin levels	pt_PT
dc.subject	Hiperbilirubinemia	pt_PT
dc.subject	Dietery compounds	pt_PT
dc.subject	Prevention	pt_PT
dc.subject	Aquired factores	pt_PT
dc.subject	Genetic	pt_PT
dc.subject	Oxidative stress	pt_PT
dc.title	Dietary compounds that modify bilirubin levels	pt_PT
dc.type	conference object
dspace.entity.type	Publication
oaire.citation.conferencePlace	Bragança	pt_PT
oaire.citation.endPage	46	pt_PT
oaire.citation.startPage	46	pt_PT
oaire.citation.title	I Congresso Nacional \| I Encontro Nacional de Estudantes Ciências Biomédicas Laboratoriais	pt_PT
person.familyName	Rodrigues
person.familyName	Vaz
person.familyName	Ferreira
person.givenName	Carina
person.givenName	Josiana A.
person.givenName	Isabel C.F.R.
person.identifier	144781
person.identifier.ciencia-id	C415-C677-0253
person.identifier.ciencia-id	171B-88BA-64F5
person.identifier.ciencia-id	9418-CF95-9919
person.identifier.orcid	0000-0001-9773-1413
person.identifier.orcid	0000-0002-6989-1169
person.identifier.orcid	0000-0003-4910-4882
person.identifier.rid	E-8500-2013
person.identifier.scopus-author-id	16305323200
person.identifier.scopus-author-id	36868826600
rcaap.rights	openAccess	pt_PT
rcaap.type	conferenceObject	pt_PT
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