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Exploring the Impact of Ultrasound-Assisted Extraction on the Phytochemical Composition and Bioactivity of Tamus communis L. Fruits

2025Journal article Open access
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datacite.subject.fosEngenharia e Tecnologia::Engenharia Química
datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.fosCiências Naturais::Ciências Biológicas
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorGouvinhas, Irene
dc.contributor.authorSaavedra, Maria José
dc.contributor.authorAlves, Maria José
dc.contributor.authorGarcia, Juliana
dc.date.accessioned2025-10-22T13:23:57Z
dc.date.available2025-10-22T13:23:57Z
dc.date.issued2025
dc.description.abstractThe health benefits of Tamus communis fruits have been associated with their high phenolic content, which comprises several flavonoids. However, the extraction methods might significantly impact these valuable compounds' bioactivity. Therefore, the current study assesses how different extraction techniques affect T. communis extracts' antioxidant, anti-aging, antimicrobial, cytotoxic, anti-inflammatory, and phenolic contents. Conventional method (TCE-CM) and ultrasound-assisted extraction (TCE-UM) were the methods employed. Results: The increased phenolic content of TCE-UM, particularly flavonoids and phenolic acids, was demonstrated to be a contributing factor to its higher biological activity. Key enzymes linked to dermatological conditions, such as elastase, collagenase, hyaluronidase, and tyrosinase, were significantly inhibited by both extracts at 1 mg/mL; TCE-UM showed the highest tyrosinase inhibition (65.61 +/- 5.21%) compared to TCE-CM (21.78 +/- 2.19%). TCE-UM also demonstrated exceptional antibacterial performance, showing notable antibiofilm and metabolic inactivation effects and potent activity against pathogens such as Staphylococcus aureus, Escherichia coli, and Candida albicans. Both extracts showed concentration-dependent anti-inflammatory properties; TCE-UM had a lower IC50 value (26.46 +/- 2.30%) in nitric oxide inhibition tests, suggesting stronger anti-inflammatory capabilities. These findings underscore the superior bioactivity of TCE-UM and suggest that ultrasonic extraction is a more efficient method for isolating bioactive phenolic compounds from T. communis fruits, presenting promising applications in anti-aging and antimicrobial formulations.eng
dc.description.sponsorshipThis work is supported by National Funds by FCT—Portuguese Foundation for Science and Technology, under the projects UID/04033: Centro de Investigação e de Tecnologias Agro-Ambientais e Biológicas and LA/P/0126/2020 (https://doi.org/10.54499/LA/P/0126/2020) (accessed on 21 May 2025).
dc.identifier.citationGouvinhas, Irene; Saavedra, Maria José; Alves, Maria José; Garcia, Juliana (2025). Exploring the Impact of Ultrasound-Assisted Extraction on the Phytochemical Composition and Bioactivity of Tamus communis L. Fruits. Pharmaceuticals. ISSN 1424-8247. 18:9, p. 1-20
dc.identifier.doi10.3390/ph18091342
dc.identifier.issn1424-8247
dc.identifier.urihttp://hdl.handle.net/10198/34861
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationCentre for the Research and Technology of Agro-Environmental and Biological Sciences
dc.relationInstitute for innovation, capacity building and sustainability of agri-food production
dc.relation.ispartofPharmaceuticals
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectTamus communis
dc.subjectUltrasound-assisted extraction
dc.subjectPhenolic compounds
dc.subjectAntioxidant and anti-inflammatory activity
dc.subjectAntimicrobial and anti-aging properties
dc.titleExploring the Impact of Ultrasound-Assisted Extraction on the Phytochemical Composition and Bioactivity of Tamus communis L. Fruitseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for the Research and Technology of Agro-Environmental and Biological Sciences
oaire.awardTitleInstitute for innovation, capacity building and sustainability of agri-food production
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FAGR%2F04033%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0126%2F2020/PT
oaire.citation.endPage20
oaire.citation.issue9
oaire.citation.startPage1
oaire.citation.titlePharmaceuticals
oaire.citation.volume18
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameAlves
person.givenNameMaria José
person.identifier.ciencia-idD618-B3A9-D312
person.identifier.orcid0000-0001-8506-4393
person.identifier.ridM-6624-2016
person.identifier.scopus-author-id16400584800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublication7850f8c2-8834-4d5a-b4a7-df482abd76d3
relation.isAuthorOfPublication.latestForDiscovery7850f8c2-8834-4d5a-b4a7-df482abd76d3
relation.isProjectOfPublication7abf1426-8d8b-4027-a2fc-92442b719ad0
relation.isProjectOfPublication3c81413c-6a3a-453a-bb53-9e883a270537
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