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Fixed-bed and simulated moving bed chromatography using achiral and chiral adsorbents for the complete preparative separation of a quaternary mixture

2022Conference object Open access
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dc.contributor.authorArafah, Rami
dc.contributor.authorRibeiro, António E.
dc.contributor.authorRodrigues, Alírio
dc.contributor.authorPais, Luís S.
dc.date.accessioned2023-02-01T10:38:36Z
dc.date.available2023-02-01T10:38:36Z
dc.date.issued2022
dc.description.abstractNadolol is a nonselective beta-adrenergic receptor antagonist (beta-blocker) pharmaceutical drug, widely used in the treatment of cardiovascular diseases, such as hypertension, ischemic heart disease (angina pectoris), congestive heart failure and certain arrhythmias. This drug is still being marketed as a mixture of four stereoisomers in spite of the clear evidences that only one of its four stereoisomers has the desired therapeutic effect. Preparative liquid chromatography is actually an accepted route in industry to obtain enantiomeric pure drugs. Today, the combining of different chromatographic technologies, such as fixed-bed and simulated moving bed together with the use of achiral and/or chiral adsorbents are an important improvement in performance of preparative separation of multicomponent chiral drugs into its single pure stereoisomers. This work confirms this improvement using the referred strategy with mobile phase composition optimization at both normal and reversed-phase mode. Different separation strategies were designed and optimized, enlarging the packing materials possibilities, from fully chiral (Chiralpak) to achiral (C18) combined with chiral separation. For each separation step, the optimization of the solvent composition was carried out with pure alcohol, alcohol-hydrocarbon and alcohol-water mixtures, all with a basic modifier (diethylamine), taking into account the strong basic nature of the nadolol.pt_PT
dc.description.sponsorshipThis work was financially supported by: Base Funding - UIDB/00690/2020 of CIMO - Centro de Investigação de Montanha and Base Funding - UIDB/50020/2020 of the Associate Laboratory LSRE-LCM, both supports by national funds through FCT/MCTES (PIDDAC). This work is also a result of: Project “AIProcMat@N2020 - Advanced Industrial Processes and Materials for a Sustainable Northern Region of Portugal 2020”, with the reference NORTE-01-0145-FEDER-000006, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). Rami S. Arafah is supported by a PhD Grant of Fundação para a Ciência e a Tecnologia (SFRH/BD/137966/2018).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationArafah, Rami; Ribeiro, António E.; Rodrigues, Alírio; Pais, Luís S. (2022). Fixed-bed and simulated moving bed chromatography using achiral and chiral adsorbents for the complete preparative separation of a quaternary mixture. In 18th International Symposium on Preparative and Industrial Chromatography and Allied Techniques. Lisboapt_PT
dc.identifier.urihttp://hdl.handle.net/10198/26718
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpicapt_PT
dc.relationMountain Research Center
dc.relationLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
dc.relationMulticomponent chiral separation by preparative and simulated moving bed chromatography
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectNadololpt_PT
dc.subjectResearch Subject Categories::TECHNOLOGYpt_PT
dc.titleFixed-bed and simulated moving bed chromatography using achiral and chiral adsorbents for the complete preparative separation of a quaternary mixturept_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
oaire.awardTitleMulticomponent chiral separation by preparative and simulated moving bed chromatography
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50020%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F137966%2F2018/PT
oaire.citation.conferencePlaceLisboapt_PT
oaire.citation.endPage52pt_PT
oaire.citation.startPage52pt_PT
oaire.citation.title18th International Symposium on Preparative and Industrial Chromatography and Allied Techniquespt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_NORTE
person.familyNameArafah
person.familyNameRibeiro
person.familyNamePais
person.givenNameRami
person.givenNameAntónio E.
person.givenNameLuís S.
person.identifier.ciencia-idAB16-ECBF-B886
person.identifier.ciencia-id3211-D5B0-870D
person.identifier.ciencia-id421E-0CCD-A84F
person.identifier.orcid0000-0002-7743-4988
person.identifier.orcid0000-0003-4569-7887
person.identifier.orcid0000-0002-3000-2862
person.identifier.scopus-author-id57151342900
person.identifier.scopus-author-id23390701300
person.identifier.scopus-author-id6603930478
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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