Targeting glioblastoma: a novel therapeutic approach based on natural products

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Essential oils from Côa Valley Lamiaceae species: cytotoxicity on glioblastoma cells

Publication . Marques, Mário Pedro; Delgado, Jéssica; Zuzarte, Mónica; Varela, Carla; Dias, Maria Inês; Barros, Lillian; Magalhães, Mariana; Cabral, Célia

Lavandula pedunculata (Mill.) Cav., Mentha cervina L. and Thymus mastichina (L) L. subsp. mastichina are widely used and fairly representative species of the flora and traditional uses of the Côa Valley, a Portuguese UNESCO World Heritage Site. L. pedunculata and T. mastichina are used by local populations to preserve olives, as a condiment in traditional cuisine and to aromatize bonfires on Saint John's Eve, while M. cervina is mainly used as a spice for river fish dishes. However, despite their popularity among the population and prevalence in the territory of Côa Valley, these aromatic plants are still undervalued and scientific literature on their potential as anti-cancer agents is scarce. Therefore, in this work we aim to study the therapeutic potential of the essential oils (EO) obtained from these three species, by assessing their chemical composition, secretory structures morphology and cytotoxic effect against glioblastoma cell lines

2022Conference object

Open access