Topical treatment of rare forms of ichthyosis targeting disease pathophysiology

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Characterization of Liquid Dosage Forms of Atenolol and Enalapril Maleate for Oral and Enteral Feeding Administration

Publication . Mota, Sandra; Torres, Ana; Quintas, Clara; Peres, António M.; Ferreiro, Nuno Manuel; Cruz, Rebeca; Ferreira, Helena; Almeida, Isabel F.; Casal, Susana

The limited availability of pharmaceutical formulations tailored for cardiovascular diseases in both pediatric and geriatric populations generates the need for compounded dosage forms to guarantee precise dosing and medication adherence. This study aimed to analyze the physicochemical properties and stability of formulations of atenolol and enalapril maleate prepared with a proprietary oral vehicle, SuspendIt®. To this end, palatability, injectability, pH, rheological behavior, and physical, microbiological, and chemical stability over a 180-day storage period at 25 ◦C and 5 ◦C were evaluated. Injectability tests confirmed the suitable use of both formulations for administration through enteral feeding tubes. By using a potentiometric electronic tongue, it was confirmed that the SuspendIt® vehicle effectively served as a bitter-blocking strategy for atenolol and enalapril maleate. Adequate stability throughout the storage period was confirmed in terms of the mechanical properties, pH, and effectiveness of the preservative system. The atenolol concentration remained above 90% of the initial amount, while the concentration of enalapril maleate decreased to 88% after 90 days of storage at 25 ◦C. In summary, the atenolol formulation maintained suitable chemical, physical, and microbiological stability after 180 days at both storage temperatures, while the enalapril maleate formulation remained stable up to 60 days at 25 ◦C and for 180 days at 5 ◦C.

2024Journal article

Open access

Contributions to accelerating a numerical simulation of free flow parallel to a porous plane

Publication . Schepke, Claudio; Spigolon, Roberta A.; Rufino, José; Cristaldo, Cesar F. Da C.; Pizzolato, Glener L.

Flow models over flat p orous surfaces have applications in natural processes, such as material, food, chemical processing, or mountain mudflow simulations. The development of simplified a nalytical or numerical models can predict characteristics such as velocity, pressure, deviation length, and even temperature of such flows for geophysical and engineering purposes. In this context, there is considerable interest in theoretical and experimental models. Mathematical models to represent such phenomena for fluid mechanics have continuously been developed and implemented. Given this, we propose a mathematical and simulation model to describe a free-flowing flow pa rallel toa porous material and its transition zone. The objective of the application is to analyze the influence o f t he p orous matrix on the flow u nder d ifferent m atrix p roperties. W e i mplement a Computational Fluid Dynamics scheme using the Finite Volume Method to simulate and calculate the numerical solutions for case studies. However, computational applications of this type demand high performance, requiring parallel execution techniques. Due to this, it is necessary to modify the sequential version of the code. So, we propose a methodology describing the steps required to adapt and improve the code. This approach decreases 5.3% the execution time of the sequential version of the code. Next, we adopt OpenMP for parallel versions and instantiate parallel code flows and executions on multi-core. We get a speedup of 10.4 by using 12 threads. The paper provides simulations that offer the correct understanding, modeling, and construction of abrupt transitions between free flow a nd porous media. The process presented here could expand to the simulations of other porous media problems. Furthermore, customized simulations require little processing time, thanks to parallel processing.

2025Conference paper

Restricted access