CIMO - Artigos em Revistas Indexados à WoS/Scopus
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- Advances on the Synthesis, Reactivity, and Biological Properties of 4H‐Thiochromen‐4‐(thio)one DerivativesPublication . Santos, Clementina M.M.; Silva, ArturThe aim of the present review is to provide a systematic survey on the recent advancements in the chemical synthesis of thiochromones, thiochromanones, the less explored thiochromene-4-thiones and some analogs. These compounds are used as versatile building blocks in the synthesis of other complex and polycyclic heterocyclic analogs. Highlights on biological and photophysical properties of these thio derivatives are also included and discussed. It covers the literature from 2014 to 2024, in more than 170 publications.
- Artificial intelligence tools for project management: A knowledge-based perspectivePublication . Almeida, Pedro M.; Fernandes, Gabriela; Santos, José M.R.C.A.The rapid evolution of artificial intelligence is pressing the need to understand how organisations can integrate it into namely project management to enhance performance and outcomes. Through a systematic literature review, this paper explores artificial intelligence's potential use in project management. The thematic analysis of relevant literature identified key project management knowledge areas, such as integration, scope, communication, risk and stakeholder management, were as domains where artificial intelligence holds significant potential. The study further investigates the relationship between these knowledge areas and the most suitable types of artificial intelligence tools, such as generative artificial intelligence, and machine learning algorithms for optimisation and automation, based on the dominant knowledge type each knowledge area requires, namely formal, data-driven, or tacit knowledge. Based on the main findings, the study proposes a conceptual framework for the integration of artificial intelligence tools in project management, offering valuable insights for scholars and practitioners. Moreover, guidelines for future research to accelerate the wide adoption of artificial intelligence in the field are proposed.
- Bioaccessibility Performance of Phenolic Compounds from Red Fruits During Simulated Gastrointestinal Digestion and Colonic FermentationPublication . Bortolini, Débora Gonçalves; Barros, Lillian; Maciel, Giselle Maria; Peralta, Rosane M.; Corrêa, Vanesa G.; Finimundy, Tiane Cristine; Haminiuk, Charles Windson IsidoroRed fruits are rich in phenolic compounds, particularly anthocyanins, which contribute to their vibrant colors and health benefits. However, anthocyanins are chemically sensitive during digestion, which affects their bioaccessibility. This study evaluated the impact of simulated gastrointestinal digestion on whole red fruits (oral, gastric, intestinal, and colonic phases). Total phenolic content (TPC) ranged from 8.60−50.41 mg GAE/g DW, total flavonoid content (TFC) from 1.66−10.67 mg CAT/g DW, and total monomeric anthocyanins (TMA) from 0.54−1.28 mg CYA/g DW. Antioxidant activity strongly correlated with TPC (r ≥ 0.91). High-phenolic fruits showed lower bioaccessibility compared with low-phenolic ones. HPLC-DAD-ESI/MSn identified glycosylated anthocyanins, which were highly sensitive; jaboticaba anthocyanins were nonbioaccessible, while 51.83% remained bioaccessible in raspberries. Colonic fermentation further reduced TPC and TFC, and anthocyanins were entirely degraded. These results highlight the need for innovative delivery systems to improve anthocyanin bioaccessibility and functional benefits.
- Bioactive metabolites from algae: occurrence, extraction techniques, functional properties, food applications and therapeutic prospectsPublication . Pereira, Cláudia S.G.P.; Carpena, M.; Barreira, João C.M.; Silva, Cristiana F.C.; Prieto Lage, Miguel A.; Oliveira, BeatrizThis review critically summarizes the major algal-derived bioactive compounds, including phenolics compounds (e.g., phlorotannins, bromophenols, phenolic acids), sterols (e.g., fucosterol, beta-sitosterol), and polysaccharides (e. g., carrageenan, fucoidan, ulvan), as well as key pigments such as astaxanthin, beta-carotene, lutein, violaxanthin, zeaxanthin, and chlorophylls. In addition, state-of-the-art extraction technologies including supercritical fluid extraction, pressurized liquid extraction, ultrasound assisted, microwave assisted, surfactant assisted, and enzyme assisted extractions, and carbon dioxide-expanded liquids) were systematically compared considering key parameters such as yield, versatility, compound selectivity, extract quality, cost-effectiveness, technical complexity, operational conditions, and sustainability principles. Based on this comparative evaluation, ultrasound assisted extraction emerged as the most versatile among advanced technologies, same as enzyme assisted extraction within ulterior techniques. The potential incorporation of these bioactive compounds into novel algaebased food systems, either as functional ingredients or texturizing agents, was also discussed. Moreover, their relevance in alternative therapeutic applications was also highlighted, with a proof-of-concept focused on the antiviral potential of sulfated polysaccharides (carrageenan, fucoidan, and ulvan). Overall, algae-based ingredients were found to be promising biofunctional agents for innovative food products, nutraceutical formulations, and therapeutic alternatives.
- CFD analysis of multi-layer cooling channels in three-dimensionally structured grinding wheelsPublication . Costa, Sharlane; Capela, Paulina; Hassui, Amauri; Ribeiro, J.E.; Pereira, Mário; Soares, DelfimMinimizing heat damage and surface integrity loss in grinding depends on effective cooling. Conventional techniques, however, suffer with low efficiency because of the fast air barrier restricting fluid access. Grinding wheels with internal cooling channels have been suggested to solve this; nonetheless, the impact of channel geometry and multi-layer topologies is yet unknown. This work investigates their effects on coolant flow pattern and thermal performance by means of computational fluid dynamics (CFD) simulations, experimental validation, and statistical optimization combined. The ideal arrangement was found by the Taguchi- Grey study to be 30 channels, 78 degrees inclination, 1.7 mm diameter and 2 mm interlayer distance. ANOVA determined that diameter (59.7 %) and number of channels (21.8 %) are the most influential parameters. CFD results showed that multilayer structures significantly increase fluid dispersion in the workpiece. The three-layer design stood out for providing the most uniform and dynamic fluid distribution, reducing cooling inconsistencies. Grinding tests confirmed that this configuration achieved the lowest temperatures for all different depths of cut. These findings highlight that increasing the number of flutes alone is insufficient; a three-dimensional flute structure with optimized geometry is essential to ensure efficient cooling. By integrating numerical modeling, statistical optimization, and experimental validation, this study provides a framework for designing grinding wheels with internal cooling channels, improving fluid distribution and thermal control.
- A Comprehensive Review of Fused Filament Fabrication: Numerical Modeling Approaches and Emerging TrendsPublication . Enriconi, Maria; Rodriguez, Rocío; Araújo, Márcia; Rocha, João; García-Martín, Roberto; Ribeiro, J.E.; Pisonero, Javier; Rodríguez-Martín, ManuelFused Filament Fabrication (FFF) has become a widely adopted additive manufacturing technology due to its cost-effectiveness, material versatility, and accessibility. However, optimizing process parameters, predicting material behavior, and ensuring structural reliability remain major challenges. This review analyzes state-of-the-art computational methods used in FFF, which are categorized into four main areas: melt flow dynamics, cooling and solidification, thermal-mechanical behavior, and material property characterization. Notably, the integration of Computational Fluid Dynamics (CFD) and Finite Element Analysis (FEA) has led to improved predictions of key phenomena, such as filament deformation, residual stresses, and temperature gradients. The growing use of fiber-reinforced filaments has further enhanced mechanical performance; however, this also introduces added complexity due to filler orientation effects and interlayer adhesion issues. A critical limitation across existing studies is the lack of standardized experimental validation methods, which hinders model comparability and reproducibility. This review highlights the need for unified testing protocols, more accurate multi-physics simulations, and the integration of AI-based process monitoring to bridge the gap between numerical predictions and real-world performance. Addressing these gaps will be essential to advancing FFF as a precise and scalable manufacturing platform.
- Consumer preferences for olive oil in the Iberian PeninsulaPublication . Baviera-Puig, Amparo; Lopéz-Cortés, Isabel; Pereira, José Alberto; Rodrigues, NunoThis study aims to analyse consumer preferences in the iberian Peninsula by comparing two important european Union-producing countries. in order to be able to make valid cross-cultural comparisons, we used the Best-Worst Scaling (BWS) methodology. We also performed segmentation using latent cluster analysis (lca), including all consumers analysed, regardless of country of origin, to obtain three different segments. comparing both consumers, the significant differences obtained refer to the quality-price ratio, willingness to pay and attributes considered at the time of purchase of olive oil. owing to the BWS methodology, we observe that the number of attributes that establish significant differences between the three segments (taste, brand name and packaging) is higher than in the analysis performed by country (brand name). The 3 segments obtained (“Type-experience consumers,” “external cues consumers” and “Taste seekers”) prioritise the proposed attributes differently and there are significant differences between them in terms of olive oil consumption (place of purchase and average weekly consumption). These conclusions have implications at the business level for the design and development of marketing strategies in the olive oil sector in both countries.
- Curcumin Nanoparticles as a Pigment of Polyamide Textiles: Influence of Conditions in the Exhaust Dyeing and Evaluation of Wastewater ToxicityPublication . Moraes, Katharina S.; Oliveira, Aline de; Ferreira, Bruna T. M.; Bona, Evandro; Carneiro, Jaqueline; Peron, Ana Paula; Fernandes, Marta; Zille, Andrea; Leimann, Fernanda V.; Aguiar, Catia R. Lange de; Silva, Márcia G. da; Ferreira, Alexandre J. S.; Vila, Nívea T.; Gonçalves, Odinei HessThe growing demand for eco-friendly and sustainable solutions in textile dyeing has attracted interest in natural dyes, since the synthetic counterparts may be potentially damaging to the environment and require the use of additives to efficiently bind them to the fibers. Curcumin, a natural dye derived from Curcuma longa L. rhizomes, has attracted attention due to its notable biological activity and vibrant yellow-orange hue; however, its direct application remains limited by challenges related to dye fixation and color fastness. This study aimed to evaluate the use of curcumin nanoparticles in the dyeing of polyamide 6.6, as well as to assess the toxicity level of the effluent generated during the exhaust dyeing process. Colloidally stable nanoparticles with average sizes of 454 and 419 nm were obtained with PVP (polyvinylpyrrolidone) and Poloxamer 407 as the polymeric stabilizer, respectively. A factorial 24-1 experimental design was implemented, showing a reduction in color intensity at higher dyeing temperatures, while acidic conditions enhanced dye uptake, leading to improved color depth. Two formulations were selected for a more detailed characterization. Regarding the wash currently used by the textile field, the scores found demonstrated that color did not change during washing. Excellent ratings were found in the rubbing and perspiration fastness and the ultraviolet protection factor for the textiles dyed with PVP and Poloxamer 407 stabilizers. The wastewater of the dyeing process under selected experimental conditions was evaluated with respect to the phytotoxicity, genotoxicity, and cytotoxicity in in vivo models. Based on the results, the wastewater samples analyzed may be environmentally safe.
- Effect of melatonin implants on carcass characteristics and meat quality of slow-growing chickensPublication . Nieto, Jaime; Leite, Ana; Vasconcelos, Lia; Plaza, Javier; Abecia, José-Alfonso; Revilla, Isabel; Palacios, Carlos; Teixeira, AlfredoThis study evaluated the effect of melatonin implants on carcass characteristics and meat quality of slow-growing broilers slaughtered at 43 and 97 days (d) of age. A total of 128 one day-old male broilers (Coloryeld) were randomly divided into two groups, which in turn were divided into 8 groups (replicates) of 8 broilers each one. One group (64 animals) was the control group (C) and the other received a melatonin implant (18 mg melatonin per animal) at 8 d of age (M). The animals were reared for 97 d. For the first 42 d they were kept in an enclosed facility and then allowed access to the outside. Two culls were performed: one at 43 d and one at 97 d, randomly selecting 8 chicks from each group at each time (N = 8 × 2 × 2= 32). Carcass traits and meat quality were evaluated on these samples. Chickens slaughtered at older ages had higher dead-plucked, leg and carcass weights (P < 0.05). In terms of meat quality, chickens slaughtered at 97 days had higher L* (P < 0.001), lower a*, b* and chroma values (P < 0.01), as well as lower pH (P = 0.006), higher shear strength (P < 0.001), water holding capacity (P < 0.001) and water activity (P = 0.036). The melatonin implants did not influence carcass characteristics (P>0.05). Luminosity, tone and water activity decreased with melatonin implants at 43 d of age (P <0.001), whereas pH increased (P = 0.004). At 97 d after slaughter, meat yellowness was lower (P = 0.028) and firmness increased (P = 0.029). At both time points, melatonin caused reddening of the meat (P < 0.001). Lipid oxidisability tended to be reduced, extending the shelf life of the meat (P = 0.068). The fatty acid profile was little affected by the placement of the implants. Age and melatonin have different effects on the meat quality of slow-growing chickens. While age affects several factors such as texture and fatty acid profile, melatonin improves colour, water activity and lipid oxidation. Its use could improve preservation and extend the shelf life of meat
- Enhanced Antimalarial Activity of Extracts of Artemisia annua L. Achieved with Aqueous Solutions of Salicylate Salts and Ionic LiquidsPublication . Ferreira, Ana M.; Sales, Isabela; Santos, Sónia A.O.; Santos, Tiago; Nogueira, Fátima; Mattedi, Silvana; Pinho, Simão; Coutinho, João A.P.; Freire, Mara G.Artemisinin, a drug used to treat malaria, can be chemically synthesized or extracted from Artemisia annua L. However, the extraction method for artemisinin from biomass needs to be more sustainable while maintaining or enhancing its bioactivity. This work investigates the use of aqueous solutions of salts and ionic liquids with hydrotropic properties as alternative solvents for artemisinin extraction from Artemisia annua L. Among the investigated solvents, aqueous solutions of cholinium salicylate and sodium salicylate were found to be the most promising. To optimize the extraction process, a response surface method was further applied, in which the extraction time, hydrotrope concentration, and temperature were optimized. The optimized conditions resulted in extraction yields of up to 6.50 and 6.44 mg·g-1, obtained with aqueous solutions of sodium salicylate and cholinium salicylate, respectively. The extracts obtained were tested for their antimalarial activity, showing a higher efficacy against the Plasmodium falciparum strain compared with pure (synthetic) artemisinin or extracts obtained with conventional organic solvents. Characterization of the extracts revealed the presence of artemisinin together with other compounds, such as artemitin, chrysosplenol D, arteannuin B, and arteannuin J. These compounds act synergistically with artemisinin and enhance the antimalarial activity of the obtained extracts. Given the growing concern about artemisinin resistance, the results here obtained pave the way for the development of sustainable and biobased antimalarial drugs. © 2024 The Authors. Co-published by Zhejiang University and American Chemical Society.
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