Percorrer por autor "Sankovic-Babic, Snezana"
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- An in vitro study of the origanum minutiflorum O. Schwarz & P. H. Davis and Coriandrum sativum L. essential oils as chronic tonsillitis therapeutics: antibacterial, antibiofilm, antioxidant, and cytotoxic activitiesPublication . Kostić, Marina; Ivanov, Marija; Marković, Tatjana; Sankovic-Babic, Snezana; Barros, Lillian; Calhelha, Ricardo C.; Soković, Marina; Cirić, AnaThe chemical composition and biological activity of essential oils (EOs) from leaves of Origanum minutiflorum O. Schwarz & P.H.Davis, and seeds of Coriandrum sativum L. were investigated. Chemical analyses of EOs were performed and the major components were carvacrol (81.5%) and linalool (69.6%), respectively. The antimicrobial activity was assessed against several bacteria originating from the tonsillar tissue. Activities of EOs against Staphylococcus aureus biofilm were investigated, as well as the effect of the mixture of these EOs and antibiotics against the pathogen. The antioxidant activity of both EOs was determined by TBARS assay, and examined wild oregano EO showed better activity. Also, cytotoxicity of EOs was evaluated in vitro and both EOs showed potential to inhibit further proliferation of tumor cells. This study reported for the first time the effects of EOs on chronic tonsillitis causative pathogens, supporting their role as a natural bioactive therapeutic agent with possible antimicrobial applications.
- Nitrate esters of heteroaromatic compounds as Candida albicans CYP51 enzyme inhibitorsPublication . Smiljković, Marija; Matsoukas, Minos Timotheos; Kritsi, Eftichia; Zelenko, Urska; Grdadolnik, Simona Golic; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Sankovic-Babic, Snezana; Glamočlija, Jasmina; Fotopoulou, Theano; Koufaki, Maria; Zoumpoulakis, Panagiotis; Soković, MarinaFour heteroaromatic compounds bearing nitrate esters were selected using a virtual-screening procedure as putative sterol 14a-demethylase (CYP51) Candida albicans inhibitors. Compounds were examined for their inhibition on C. albicans growth and biofilm formation as well as for their toxicity. NMR spectroscopy studies, in silico docking, and molecular dynamics simulations were used to investigate further the selectivity of these compounds to fungal CYP51. All compounds exhibited good antimicrobial properties, indicated with low minimal inhibitory concentrations and ability to inhibit formation of fungal biofilm. Moreover, all of the compounds had the ability to inhibit growth of C. albicans cells. N-(2-Nitrooxyethyl)-1Hindole- 2-carboxamide was the only compound with selectivity on C. albicans CYP51 that did not exhibit cytotoxic effect on cells isolated from liver and should be further investigated for selective application in new leads for the treatment of candidiasis.