Percorrer por autor "Ricardo, Sara"
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- I Congresso Nacional de Ciências Biomédicas Laboratoriais: livro de atasPublication . Vaz, Josiana A.; Ferro, Amadeu; Pais, Clarisse; Pimentel, Maria Helena; Ricardo, SaraEste livro de atas contem os artigos do I Congresso Nacional de Ciências Biomédicas Laboratoriais, realizado em 28 a 30 de Outubro de 2016.
- I Congresso Nacional de Ciências Biomédicas Laboratoriais: livro de resumosPublication . Vaz, Josiana A.; Ferro, Amadeu; Pais, Clarisse; Pimentel, Maria Helena; Ricardo, SaraEste livro contém os resumos do I Congresso Nacional de Ciências Biomédicas Laboratoriais, realizado nos dias 28 a 30 de Outubro de 2016, no Instituto Politécnico de Bragança
- In Silico Identification of Six Mushroom-Derived Sterol and Triterpenoid Compounds as Potential P-Glycoprotein Modulators in Multidrug ResistancePublication . Fonseca, Jéssica; Shiraishi, Carlos S.H.; Abreu, Rui M.V.; Ricardo, Sara; Vaz, Josiana A.The overexpression of P-glycoprotein (P-gp) is often directly related to multidrug resistance (MDR), one of the greatest challenges in cancer treatment. This transmembrane efflux pump decreases the intracellular concentrations of chemotherapy drugs, reducing their effectiveness and resulting in treatment failure. This work used in silico methods to assess the potential of bioactive chemicals produced from mushrooms as P-gp modulators. A database comprising 211 bioactive compounds from mushrooms was investigated using molecular docking and virtual screening techniques against the P-gp structure. The compounds ergosta-4,6,8(14),22-tetraen-3-one, lucidumol A, (22E,24S)-ergosta-4,22-dien-3-one, antcin K, 3,11-dioxolanosta-8,24(Z)-diene-26-oic acid, and (22E)-19-norergosta-5,7,9,22-tetraen-3 beta-ol were identified as the six best candidates from our database of mushroom compounds based on their binding affinities, toxicity predictions, and pharmacological properties assessed through ADME analyses (absorption, distributions, metabolism, and excretion). These six compounds exhibited strong binding affinities, with binding energies ranging from -12.31 kcal/mol to -10.93 kcal/mol, all showing higher affinities than the control, tariquidar, which had a binding energy of -10.78 kcal/mol. Toxicity predictions indicated favorable safety profiles for all six, while ADME analyses found that all six compounds had high oral bioavailability and a low probability of acting as P-gp substrates. These results position bioactive mushroom compounds, particularly these six, as promising P-gp modulators, suggesting positive outcomes in cancer treatment.
- The Potential of Mushroom Extracts to Improve Chemotherapy Efficacy in Cancer Cells: A Systematic ReviewPublication . Fonseca, Jéssica; Vaz, Josiana A.; Ricardo, SaraChemoresistance is a challenge in cancer treatment, limiting the effectiveness of chemotherapy. Mushroom extracts have shown potential as treatments for cancer therapies, offering a possible solution to overcome chemoresistance. This systematic review aimed to explore the role of mushroom extracts in enhancing chemotherapy and reversing chemoresistance in cancer cells. We searched the PubMed, Web of Science and Scopus databases, following the PRISMA guidelines, and registered on PROSPERO. The extracts acted by inhibiting the proliferation of cancer cells, as well as enhancing the effect of chemotherapy. The mechanisms by which they acted included regulating anti-apoptotic proteins, inhibiting the JAK2/STAT3 pathway, inhibiting the ERK1/2 pathway, modulating microRNAs and regulating p-glycoprotein. These results highlight the potential of mushroom extracts to modulate multiple mechanisms in order to improve the efficacy of chemotherapy. This work sheds light on the use of mushroom extracts as an aid to chemotherapy to combat chemoresistance. Although studies are limited, the diversity of mushrooms and their bioactive compounds show promising results for innovative strategies to treat cancer more effectively. It is crucial to carry out further studies to better understand the therapeutic potential of mushroom extracts to improve the efficacy of chemotherapy in cancer cells.