Browsing by Author "Prada, Justina"
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- Animal tuberculosis: gross lesions and anatomopathological diagnosisPublication . Quintas, Helder; Prada, Justina; Fontes, Maria da Conceição; Coelho, Ana Cláudia; Pires, IsabelAnimal tuberculosis (TB) is a zoonotic disease with worldwide distribution that can cause serious animal infections with economic and public health concerns. In its turn, human TB is currently one of the leading causes of death in the world due to a curable disease. Although the diagnosis demands microbiological culture confirmation, anatomopathological diagnosis of suggestive lesions often provides a presumptive diagnosis of TB and is used by veterinary professionals as a central tool, either through monitoring at slaughter or when and where applicable, in clinical practice. Throughout this chapter, the anatomopathological diagnosis of animal TB will be reviewed, underling the peculiarities and similarities of TB lesions in ruminants, dogs, cats, pigs, and horses. Additionally, the importance of TB anatomopathological diagnosis in meat inspection is discussed. The last aim of this chapter is to emphasize that veterinarians and their teams, whether clinicians, pathologists, microbiologists, epidemiologists, anatomopathologists, and meat inspectors, have a central role in TB control and eradication. Only with the involvement of multidisciplinary teams of veterinary and human health professionals will it be possible to effectively combat animal and human TB in an integrated “One Health” perspective.
- Diagnosis of mycobacteriosis in goats: tuberculosis and paratuberculosisPublication . Quintas, Helder; Pires, Isabel; Prada, Justina; Fontes, Maria da Conceição; Coelho, Ana CláudiaTwo main diseases are caused by mycobacterium in goats. Tuberculosis, caused by Mycobacterium bovis or M. caprae, produces severe respiratory distress in goats or remain in a subclinical state. Another important mycobacteriosis in goats is paratuberculosis or Johne’s disease caused by M. avium subsp. paratuberculosis is characterized by chronic emaciation. In mycobacterial infections, clinical signs are insufficient to establish a diagnosis. Histopathological diagnosis of tuberculosis compatible lesions usually allows a presumptive diagnosis of the disease. The gold standard test for Mycobacterium spp. diagnosis is the microbiological culture but can take several weeks. During the past several years, many molecular methods have been developed for direct detection, species identification, and drug susceptibility testing of mycobacteria. Throughout this chapter, it will be reviewed the different methods of diagnosis of Mycobacterium spp. in goats. The main aim of this chapter is to describe the different methods of diagnosis with their advantages and disadvantages.
- The diagnostic challenges of ovine pulmonary adenocarcinomaPublication . Quintas, Helder; Pires, Isabel; Garcês, Andreia; Prada, Justina; Silva, Filipe; Alegria, NunoOvine pulmonary adenocarcinoma (OPA), also known as sheep pulmonary adenomatosis and jaagsiekte, is a contagious pulmonary tumor of sheep, characterized by neoplastic proliferation of type II pneumocyte and club cells. OPA is induced by the oncogenic activity of the envelope glycoprotein (Env) of exogenous jaagsiekte sheep retrovirus (JSRV). This disease is associated with significant economic losses in numerous sheep raising countries. The onset of suggestive clinical signs is often late, making difficult the early diagnosis of the disease and timely implementation of control measures on the affected farms. Further, the lack of diagnostic tests that can be performed routinely by veterinary clinicians to accurately assess infected animals (e.g., serological or others) means that the true prevalence at flock level is not known. Imaging diagnostic methods (e.g., ultrasound, X-ray and computed tomography) can be used to support the clinical diagnosis, even in pre-clinical stages in affected flocks. The diagnosis must be confirmed by PCR of nasal excretions or immunohistochemistry and PCR of tumor lesions. No vaccine for OPA has yet been developed. Thus, in this work, we review the main methods of diagnosis of OPA in order to support the clinician in the identification of the disease, avoid underdiagnosis and allow the implementation of suitable measures to prevent and control its spread.
- Tuberculosis: integrated studies for a complex disease 2050Publication . Rezaei, Nima; Hosseini, Nastaran-Sadat; Saghazadeh, Amene; Fateh, Abolfazl; Duse, Adriano; Ahmad, Aijaz; Braley, Alexander E.; Tahta, Alican; Kamboj, Alisha; Khan, Amer Hayat; Coelho, Ana Cláudia; Licona-Cassani, Cuauhtémoc; Fast, Cynthia D.; Pérez-Martínez, Damián; Pizzol, Damiano; Perlman, David C.; Philips, Dennis; Viveros, Diana; Fisher, Dina A.; Butov, Dmytro; Egelund, Eric F.; Marimani, Musa; Igartua, Everest de; Bhatt, Garima; Mgode, Georgies; Quaglio, Gianluca; Putoto, Giovanni; Mini, G.K.; Thomas-Richardson, Govind; Wylie, Greg; Fernandes, Guilherme Felipe dos Santos; Bermúdez, Gustavo; Srinivas, Nanduri; Quintas, Helder; Verma, Himanshu; Eoh, Hyungjin; Putera, Ikhwanuliman; Sivokozov, Ilya; Pires, Isabel; Lee, Jae Jin; Lombard, Jason E.; Santos, Jean Leandro dos; Zellweger, Jean-Pierre; Beyene, Negussie; Thomas-Richardson, Jenu; Lordson, Jinbert; Prates, João Lucas; Cervantes, Jorge; Porcel, José M.; Vaquero, Juan José; Prada, Justina; Kamboj, Kamal; Tabbara, Khalid F.; Mussie, Kirubel Manyazewal; Arenas, Nelson E.; Patel, Krupesh; Porcel, Laura; Fiebig, Lena; Mohan, Malu; Yadav, Mange Ram; López-R, Marcela; Correia-Neves, Margarida; Fontes, Maria da Conceição; Sant´Anna, Maria de Fátima Pombo Bazhuni; Cañadas-Ortega, Marina; Cardoso, Nicole; Singh, Meenakshi; Lause, Michael; Maya-Hoyos, Milena; Omrani, Mir Davood; Palmer, Mitchell V.; Ahmad, Mohammad Naiyaz; Seid, Mohammed Assen; Chauhan, Monica; Saxena, Mridula; Oliveira, Olena; Silakari, Om; Inlamea, Osvaldo; Tanrıverdi, Özgür; Boggiatto, Paola M.; Fuso, Andrea; Santos, Paola; Mejía-Ponce, Paulina; Soares, Pedro; Sell, Philip; Murumkar, Prashant R.; Devanandan, Praveen; Zheng, Qi; Lim, Rachel K.; Aurílio, Rafaela Baroni; Ghuge, Rahul B.; Varón, Andrés; Barot, Rahul R.; Rahul; Puvvada, Ranadheer Chowdary; Duarte, Raquel; Singh, Ravi; Sinha, Richa; Nora, Rina La Distia; Burny, Robert; Zenteno-Cuevas, Roberto; Mali, Sagar; Trajman, Anete; Shoughy, Samir S.; Tarashi, Samira; Mishra, Sapna; Malasala, Satyaveni; Mamishi, Setareh; Siadat, Seyed Davar; Choudhary, Shalki; Mahmoudi, Shima; Chopra, Sidharth; Nandi, Sisir; Saxena, Anil Kumar; Faisal, Sobia; Goel, Sonu; Huszár, Stanislav; Field, Stephen K.; Singh, Sushil Kumar; Rito, Teresa; Butova, Tetiana; Manning, Thomas; Werf, Tjip S. van der; Myasoedov, Valeriy; Ganeshpurkar, Ankit; Vásquez, Vanessa; Muthukumar, Vijey Aanandhi; Singh, Vinayak; Hall, Walter A.; Hikmahwati, Wandya; Turgut, Yaşar Barış; Thaker, Yatri; Kawabata, Yoshinori; Reus, Yvette A. de; Casapao, Anthony M.; Tkachenko, Anton; Devnikar, Anushka V.; Moshiri, Arfa; Muñoz-Barrutia, Arrate; Dasgupta, Arunava; Natarajan, Arvind; Gupta, Ashish; Coyne, Ashlan J. Kunz; Jordan, Ashly E.; Kumar, Ashok; Ergeshov, Atadzhan; Pourakbari, Babak; Joshi, Basant; Chavarro-Portillo, Bibiana; Soto, Carlos Y.; Kanipe, Carly; Schmidt, Christiane Mello; Cox, Christophe; Gómez-Cruz, Clara; Cardoso, Claudete Aparecida Araújo; Sant´Anna, Clemax Couto; Johnson, Courtney; Rodríguez-Silva, Cristhian N.; Rosales, CristianTuberculosis (TB) has been a disease for centuries with various challenges [1]. Like other places where challenges and opportunities come together, TB challenges were the inspiration for the scientific community to mobilize different groups for the purpose of interest. For example, with the emergence of drug resistance, there has been a huge volume of research on the discovery of new medicines and drug delivery methods and the repurposing of old drugs [2, 3]. Moreover, to enhance the capacity to detect TB cases, studies have sought diagnostics and biomarkers, with much hope recently expressed in the direction of point-of-care tests [4]. Despite all such efforts as being highlighted in 50 Chapters of this volume, we are still writing about TB and thinking about how to fight this old disease–implying that the problem of TB might be complex, so calling the need for an integrated science to deal with multiple dimensions in a simultaneous and effective manner. We are not the first one; there have been proposed integrated platform for TB research, integrated prevention services, integrated models for drug screening, integrated imaging protocol, integrated understanding of the disease pathogenesis, integrated control models, integrated mapping of the genome of the pathogen, etc. [5–12], to name some. These integrated jobs date back decades ago. So, a question arises: why is there a disease named TB yet? It might be due to the fact that this integration has happened to a scale that is not global, and so TB remains to be a problem, especially in resource-limited settings. Hope Tuberculosis: Integrated Studies for a Complex Disease helps to globalize the integrated science of TB.