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Browsing by Author "Pires, A."

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  • Magnetoliposomes as carriers for promising antitumor thieno[3,2-b]pyridin-7-arylamines: photophysical and biological studies
    Publication . Rodrigues, Ana Rita O.; Almeida, Bernardo G.; Rodrigues, Juliana M.; Queiroz, Maria João R.P.; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Pires, A.; Pereira, André M.; Araújo, José Pedro; Coutinho, Paulo J.G.; Castanheira, Elisabete M.S.
    Magnetoliposomes containing superparamagnetic manganese ferrite nanoparticles were tested as nanocarriers for two new promising antitumor drugs, a N-(3-methoxyphenyl)thieno[3,2-b]pyridin-7-amine (1) and a N-(2-methoxy-phenyl)thieno[3,2-b] pyridin-7-amine (2). The fluorescence emission of both compounds was studied in different polar and non-polar media, evidencing a strong intramolecular charge transfer character of the excited state of both compounds. These in vitro potent antitumor thienopyridine derivatives were successfully incorporated in both aqueous and solid magnetoliposomes, with encapsulation efficiencies higher than 75%. The magnetic properties of magnetoliposomes containing manganese ferrite nanoparticles were measured for the first time, proving a superparamagnetic behaviour. Growth inhibition assays on several human tumor cell lines showed very low GI 50 values for drug-loaded aqueous magnetoliposomes, comparing in most cell lines with the ones previously obtained using the neat compounds. These results are important for future drug delivery applications using magnetoliposomes in oncology, through a dual therapeutic approach (simultaneous chemotherapy and magnetic hyperthermia).
    2017Journal article Open access Show more
  • Uma rede de soutos demonstração
    Publication . Carneiro, Rui; Batista, J.; Pereira, Abel; Droga, Rui; Espírio-Santo, J.; Pires, A.; Carmo, M.; Seco, F.; Freitas, Mariano; Ramos, Carlos; Raimundo, F.; Viana, Hugo; Ramos, António; Rodrigues, Raquel Oliveira; Patrício, Maria Sameiro; Gomes-Laranjo, José
    A estrutura organizativa da rede é constituída por 8 soutos demonstração (SD) e está assim definida: SD Salgueiros- Vinhais (SD S_V); Gestão- Arborea | Supervisão- IPB SD Parada – Bragança (SD P_B); Gestão- Sortegel | Supervisão- IPB SD Lagoa – Vila Pouca de Aguiar (SD L_VPA); Gestão- AguiarFloresta | Supervisão- UTAD SD Carrazedo Montenegro – Valpaços (SD CM_V); Gestão- Agrifuturo | Supervisão- UTAD SD Refoios do Lima – Ponte de Lima (SD RL_PL); Gestão- AFLima | Supervisão- IPVC SD Penela da Beira – Penedono (SD PB_P); Gestão- Coopenela | Supervisão- IPV SD Porto da Espada – Marvão (SD PE_M): Gestão Câmara Municipal Marvão | Supervisão- IPCB SD Folhadela - Vila Real (SD UTAD_VR); Gestão | Supervisão- UTAD (este SD é constituído pelo Banco de Germoplasma da UTAD, que fornece material de enxertia para os outros SD).
    2022Book part Open access Show more