Browsing by Author "Pinto, Maria de Lurdes"
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- Scrapie at abattoir: monitoring, control, and differential diagnosis of wasting conditions during meat inspectionPublication . Esteves, Alexandra; Vieira-Pinto, Madalena; Quintas, Helder; Orge, Leonor; Gama, Adelina; Alves, Anabela; Seixas, Fernanda; Pires, Isabel; Pinto, Maria de Lurdes; Mendonça, Ana Paula; Lima, Carla; Machado, Carla Neves; Silva, João Carlos; Tavares, Paula; Silva, Filipe; Bastos, Estela; Pereira, Jorge; Gonçalves-Anjo, Nuno; Carvalho, Paulo; Sargo, Roberto; Matos, Ana; Figueira, Luís; Pires, Maria dos AnjosWasting disease in small ruminants is frequently detected at slaughterhouses. The wasting disorder is manifested by the deterioration of the nutritional and physiological state of the animal indicated by thinness, emaciation, and cachexia. Evidence of emaciation and cachexia, alone, are pathological conditions leading to carcass condemnation during an inspection. Several diseases are associated with a wasting condition, including scrapie, pseudotuberculosis, tuberculosis, paratuberculosis, Maedi Visna, and tumor diseases. On the other hand, parasitic diseases, nutrition disorders, exposure or ingestion of toxins, metabolic conditions, inadequate nutrition due to poor teeth, or poor alimentary diet are conditions contributing to poor body condition. Classical and atypical scrapie is naturally occurring transmissible spongiform encephalopathies in small ruminants. The etiological agent for each one is prions. However, each of these scrapie types is epidemiologically, pathologically, and biochemically different. Though atypical scrapie occurs at low incidence, it is consistently prevalent in the small ruminant population. Hence, it is advisable to include differential diagnosis of this disease, from other possibilities, as a cause of wasting conditions detected during meat inspection at the abattoir. This manuscript is a review of the measures in force at the abattoir for scrapie control, focusing on the differential diagnosis of gross lesions related to wasting conditions detected in small ruminants during meat inspection.
- Supplementation of an anthocyanin-rich elderberry (Sambucus nigra L.) extract in FVB/n mice: a healthier alternative to synthetic colorantsPublication . Azevedo, Tiago; Ferreira, Tiago; Ferreira, João Miguel Mendes; Teixeira, Filipa; Ferreira, Diana; Silva-Reis, Rita; Neuparth, Maria João; Pires, Maria João; Pinto, Maria de Lurdes; Costa, Rui Miguel Gil; Bastos, Margarida M.S.M.; Medeiros, Rui; Felix, Luis; Venâncio, Carlos; Dias, Maria Inês; Gaivão, Isabel; Barros, Lillian; Oliveira, Paula A.Featured Application Due to anthocyanins' potential as colorants, this anthocyanin-rich elderberry extract presents a healthier alternative to commercially available colorants and has the potential to be used at industry level. Sambucus nigra L., popularly known as elderberry, is renowned for its amazing therapeutic properties, as well as its uses as a food source, in nutraceuticals, and in traditional medicine. This study's aim was to investigate the effects of an elderberry extract (EE) on mice for 29 days, as well as the safety of the extract when used as a natural colorant. Twenty-four FVB/n female mice (n = 6) were randomly assigned to one of four groups: control, 12 mg/mL EE (EE12), 24 mg/mL EE (EE24), or 48 mg/mL EE (EE48). The predominant anthocyanins detected were cyanidin-3-O-sambubioside and cyanidin-3-O-glucoside. Food and drink intake were similar between groups, with the exception of EE48, who drank significantly less compared with the Control. Biochemical analysis of the liver showed that the changes observed in histological analysis had no pathological significance. The EE, at doses of 24 and 48 mg/mL, significantly reduced the oxidative DNA damage compared with the non-supplemented group. The S. nigra extract showed a favorable toxicological profile, affording it potential to be used in the food industry.