Percorrer por autor "Freitas, Rilton Alves de"
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- Nanoencapsulation of Curcuma longa L. extract for the treatment of experimental colitisPublication . Luz, Débora dos Anjos Weber; Rampazzo, Ana Paula de Santi; Borges, Stephanie Carvalho; Neves, Camila Quaglio; Santos, Priscila Dayane Freitas dos; Buttow, Nilza Cristina; Pires, Cassiano; Freitas, Rilton Alves de; Amado, Ciomar Aparecida Bersani; Gonçalves, Odinei Hess; Natali, Maria Raquel MarçalInflammatory bowel diseases (IBDs) are gastrointestinal chronic inflammatory diseases characterized by chronic and recurrent intestinal ulcerations. Curcuminoids are naturally occurring polyphenolic compounds with remarkable bioactivity; however, their low water affinity and bioavailability usually hinder their application. Encapsulation techniques can be coupled with extraction procedures to yield nanoparticles that may have enhanced properties. In this work, curcuminoids were extracted from rhizomes of Curcuma longa L. and simultaneously encapsulated using ultrasound. The characterization of the curcuminoids nanoparticles showed that particles ranging from 124 ± 81 to 252 ± 68 nm were formed, and the main properties of the curcuminoids were maintained after encapsulation. Experimental colitis was induced in rats by 2,4,6-trinitrobenzene sulfonic acid, and they were subsequently treated with 10, 25, or 50 mg kg-1 of nanoencapsulated curcuminoids for 7 days through gavage, during which the disease activity index (DAI) was evaluated. Then the rats were euthanized, and the distal colon was removed for macroscopic analysis and the assessment of the activity of the enzymes myeloperoxidase and N-acetylglucosaminidase. The dose of 25 mg kg-1 of nanoencapsulated curcuminoids reduced the DAI and the activity of inflammatory enzymes compared to the untreated group and was established as the minimum effective dose to be used in the treatment of this model of experimental colitis in rats.
- Unconventional and conventional pickering emulsions: perspectives and challenges in skin applicationsPublication . Hazt, Bianca; Parchen, Gabriela Pereira; Amaral, Lilian Fernanda Martin do; Gallina, Patricia Rondon; Martin, Sandra; Gonçalves, Odinei Hess; Freitas, Rilton Alves dePickering emulsions are free from molecular and classical surfactants and are stabilized by solid particles, creating long-term stability against emulsion coalescence. Additionally, these emulsions are both environmen-tally and skin-friendly, creating new and unexplored sensorial perceptions. Although the literature mostly de-scribes conventional emulsions (oil-in-water), there are unconventional emulsions (multiple, oil-in-oil and water -in-water) with excellent prospects and challenges in skin application as oil-free systems, permeation enhancers and topical drug delivery agents, with various possibilities in pharmaceutical and cosmetic products. However, up to now, these conventional and unconventional Pickering emulsions are not yet available as commercial products. This review brings to the discussion some important aspects such as the use of phases, particles, rheological and sensorial perception, as well as current trends in the development of these emulsions.