Browsing by Author "Favero, Yonah"
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- Application of Hydralcoholic extracts of Salvia officinalis and Salvia elegans in cosmetic formulationsPublication . Favero, Yonah; Silva, Laryssa da; Almeida, Daiana; Pereira, Olívia R.; Sousa, Maria JoãoSalvia Officinalis and Salvia elegans are shrubs belonging to the genus Salvia, family of the Lamiaceae, easily found in the Mediterranean region, Mexico and Guatemala respectively. In addition to traditional medicine, S. officinalis is of great importance to the pharmaceutical, cosmetic and food industries. (Cuvelier et al., 1996; Martins et al., 1998 in Povh & Ono, 2008), whereas S. elegans is known in cooking as a preservative or flavoring (Pereira et al., 2014). Natural products have increased, discovering new therapeutic indications, meeting the demands of the world population taking into account their quality and safety. In this study, the focus is on phenolic compounds as an active ingredient in an anti-age formulation. Carbopol and methylcellulose-based gel was prepared together with Salvia officinalis and Salvia elegans hydroalcoholic extract as their active principle by performing physical-chemical, organoleptic gel stability tests and performing the eye irritability test (HET-CAM), beyond performing hydrodistillation at Clevenger. The essential oil was extracted by steam entrainment, yielding after 3 hours. The hydroalcoholic principle gels were prepared at three different concentrations, 1.25; 2.5 and 5%, and then tests were performed to evaluate the stability of the product obtained as: light cycles, freeze / thaw cycles, centrifugation and vortexing, pH determination, microbiological analysis and HET-CAM test. According to the results, the pH test showed changes for the two plants containing their gels but never exceeding the ideal limits for the skin, even when exposed to the light cycle, only the color that was changed after 15 days, in the different concentrations. In freezing / thawing tests for Salvia officinalis the methylcellulose gel did not change, the carbopol gel did change the appearance but small changes are acceptable as the samples are subjected to extreme heat (45 ° C) and cold temperatures. (-20 ° C). For Salvia elegans there was a change in appearance and pH, which was also changed in the methylcellulose gel. All pH changes do not lead to considerer the gel as inappropriate. In microbiological tests the oils have a moderate effect, while in the other tests there were no changes. Centrifugation and vortex tests were performed for both gels using both plants with only hydroalcoholic extract at different concentrations and there was no change. All gels had an alcoholic odor during the tests. It can be concluded that carbopol and methylcellulose gel do not appear to have any detrimental effects when used in this cosmetic product, even when used in conjunction with plant essential oil and can therefore be used as an anti-aging formulation. However, the development of more tests is extremely important as toxicity tests, but stability tests already have promising results.
- Application of Hydralcoholic extracts of Salvia officinalis and Salvia elegans in cosmetic formulationsPublication . Favero, Yonah; Silva, Laryssa da; Almeida, Daiana; Pereira, Olívia R.; Sousa, Maria JoãoSalvia Officinalis and Salvia elegans are shrubs belonging to the genus Salvia, family of the Lamiaceae, easily found in the Mediterranean region, Mexico and Guatemala respectively. In addition to traditional medicine, S. officinalis is of great importance to the pharmaceutical, cosmetic and food industries. (Cuvelier et al., 1996; Martins et al., 1998 in Povh & Ono, 2008), whereas S. elegans is known in cooking as a preservative or flavoring (Pereira et al., 2014). Natural products have increased, discovering new therapeutic indications, meeting the demands of the world population taking into account their quality and safety. In this study, the focus is on phenolic compounds as an active ingredient in an anti-age formulation. Carbopol and methylcellulose-based gel was prepared together with Salvia officinalis and Salvia elegans hydroalcoholic extract as their active principle by performing physical-chemical, organoleptic gel stability tests and performing the eye irritability test (HET-CAM), beyond performing hydrodistillation at Clevenger. The essential oil was extracted by steam entrainment, yielding after 3 hours. The hydroalcoholic principle gels were prepared at three different concentrations, 1.25; 2.5 and 5%, and then tests were performed to evaluate the stability of the product obtained as: light cycles, freeze / thaw cycles, centrifugation and vortexing, pH determination, microbiological analysis and HET-CAM test. According to the results, the pH test showed changes for the two plants containing their gels but never exceeding the ideal limits for the skin, even when exposed to the light cycle, only the color that was changed after 15 days, in the different concentrations. In freezing / thawing tests for Salvia officinalis the methylcellulose gel did not change, the carbopol gel did change the appearance but small changes are acceptable as the samples are subjected to extreme heat (45 ° C) and cold temperatures. (-20 ° C). For Salvia elegans there was a change in appearance and pH, which was also changed in the methylcellulose gel. All pH changes do not lead to considerer the gel as inappropriate. In microbiological tests the oils have a moderate effect, while in the other tests there were no changes. Centrifugation and vortex tests were performed for both gels using both plants with only hydroalcoholic extract at different concentrations and there was no change. All gels had an alcoholic odor during the tests. It can be concluded that carbopol and methylcellulose gel do not appear to have any detrimental effects when used in this cosmetic product, even when used in conjunction with plant essential oil and can therefore be used as an anti-aging formulation. However, the development of more tests is extremely important as toxicity tests, but stability tests already have promising results.
- Desenvolvimento e análise de estabilidade de um gel anti-idade com extracto hidroalcoólico de Salvia officinalisPublication . Favero, Yonah; Silva, Laryssa da; Almeida, Daiana; Pereira, Olívia R.; Sousa, Maria JoãoO desenvolvimento de cosméticos com produtos naturais aumentou, mas há que considerar sua eficácia. Os testes de estabilidade pretendem avaliar dados da qualidade do produto quando exposto a variáveis:temperatura, luz, etc. São dados importantes para definir prazos de validade, segurança, atendendo à norma ISO22716. Salvia officinalis pertence à família Lamiaceae, é uma planta com propriedades medicinais, como, anti-inflamatória. Objetivos:Formulação de gel de carbopol anti-idade com extratos de Salvia officinalis como princípio ativo e conservante. Métodos:Extraiu-se o óleo essencial por arrastamento de vapor, obteve-se o rendimento. Preparou-se o gel com extrato hidroalcoólico nas concentrações:1,25;2,5 e 5%. Testes para avaliar o produto:ciclos de luz, ciclos de congelamento/descongelamento, centrifugação e vórtex, temperatura, determinação do pH, análises microbiológicas e teste HET-CAM. Resultados:O pH mostrou alterações, mas nos limites adequados à pele. O gel com extrato apresentou coloração verde que se intensificou com o aumento da concentração. No ciclo de congelamento/descongelamento, o aspecto não apresentou alterações. No ciclo de luz, a formulação perdeu parte da cor verde, devido à luz. Os outros ensaios não tiveram alterações. Ensaios microbiológicos mostraram que os óleos essenciais têm um efeito moderado, nestas concentrações. Em HET-CAM, apresentaram resultado negativo.
- Desenvolvimento e análise de estabilidade de um gel anti-idade com extracto hidroalcoólico de Salvia officinalisPublication . Favero, Yonah; Silva, Laryssa da; Almeida, Daiana; Pereira, Olívia R.; Sousa, Maria JoãoO desenvolvimento de cosméticos com produtos naturais aumentou, mas há que considerar sua eficácia. Os testes de estabilidade pretendem avaliar dados da qualidade do produto quando exposto a variáveis:temperatura, luz, etc. São dados importantes para definir prazos de validade, segurança, atendendo à norma ISO22716. Salvia officinalis pertence à família Lamiaceae, é uma planta com propriedades medicinais, como, anti-inflamatória. Objetivos:Formulação de gel de carbopol anti-idade com extratos de Salvia officinalis como princípio ativo e conservante. Métodos:Extraiu-se o óleo essencial por arrastamento de vapor, obteve-se o rendimento. Preparou-se o gel com extrato hidroalcoólico nas concentrações:1,25;2,5 e 5%. Testes para avaliar o produto:ciclos de luz, ciclos de congelamento/descongelamento, centrifugação e vórtex, temperatura, determinação do pH, análises microbiológicas e teste HET-CAM. Resultados:O pH mostrou alterações, mas nos limites adequados à pele. O gel com extrato apresentou coloração verde que se intensificou com o aumento da concentração. No ciclo de congelamento/descongelamento, o aspecto não apresentou alterações. No ciclo de luz, a formulação perdeu parte da cor verde, devido à luz. Os outros ensaios não tiveram alterações. Ensaios microbiológicos mostraram que os óleos essenciais têm um efeito moderado, nestas concentrações. Em HET-CAM, apresentaram resultado negativo.
- Desenvolvimento e estabilidade de um gel anti-idade com extracto hidroalcoólico de Salvia SP.Publication . Favero, Yonah; Silva, Laryssa da; Almeida, Daiana; Pereira, Olívia R.; Sousa, Maria JoãoIntroduction: The incessant search for products from nature to apply in the search for treatment, cure or even the well-being associated with the aesthetics itself, has strongly collaborated to deepen the area of study and knowledge, so as to meet the demands of the world population. Objectives: This work aimed at the development and evaluation of the stability of two gels formulations (carbopol and methylcellulose) from the incorporation of the essential oils of the species S. officinalis and S. elegans and their hydroalcoholic extract. Methods: Physicochemical stability, organoleptic gel tests, eye irritability test (HET-CAM test) and Clevenger hydrodistillation were performed to determine the oil yield and to use them as a natural preservative in the gels. Results: As significant results we have: In light cycle tests there was only a color change after 15 days. In freeze / thaw tests there was a change in carbopol gel for S. officinalis in appearance and for S. elegans in pH and appearance, whereas in methylcellulose gel in S. elegans there was only change in pH. The accelerated stability test showed alteration for both gels, in the samples containing carbopol gel there was color change and evaporation of part of the gel, while in methylcellulose the complete dehydration. Conclusions: The samples of the gels with hydroalcoholic extract of S. elegans and S. officinalis in concentrations of 5%, 2.5% and 1.25% obtained good stability according to the tests to which they were submit.
- Desenvolvimento e estabilidade num gel anti-idade com extracto hidroalcoólico de Salvia sp.Publication . Favero, Yonah; Silva, Laryssa da; Almeida, Daiana; Pereira, Olívia R.; Sousa, Maria JoãoA Salvia officinalis vinda do Oriente Médio e do Mediterrâneo e Salvia elegans mais conhecida como Salva-ananás vinda do México e Guatemala pertencem a família Lamiaceae e são cultivadas como ervas medicinais e aromáticas. Para poder atender as necessidades cosmetologias da população, desenvolvem-se produtos visando sua eficácia, segurança e qualidade levando em conta características físico-químicas. (Silva et al.,2015). O principal objectivo do trabalho foi desenvolver o gel com duas plantas da família Salvia utilizando seus excipientes e princípios ativos. Fez-se avaliação de estabilidade físico-quimica e organoléptica dos géis. Os géis desenvolvidos (base de carbopol e base de metilcelulose) apresentaram boa estabilidade nos testes realizados, pelo que podem ser propostos para desenvolver produtos cosméticos no futuro.